Publication

Surface-modified electrodes in the mimicry of oxidative drug metabolism

Yuan, T., Permentier, H. & Bischoff, R., 1-Jul-2015, In : TrAC-Trends in Analytical Chemistry. 70, p. 50-57 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Yuan, T., Permentier, H., & Bischoff, R. (2015). Surface-modified electrodes in the mimicry of oxidative drug metabolism. TrAC-Trends in Analytical Chemistry, 70, 50-57. https://doi.org/10.1016/j.trac.2015.01.017

Author

Yuan, Tao ; Permentier, Hjalmar ; Bischoff, Rainer. / Surface-modified electrodes in the mimicry of oxidative drug metabolism. In: TrAC-Trends in Analytical Chemistry. 2015 ; Vol. 70. pp. 50-57.

Harvard

Yuan, T, Permentier, H & Bischoff, R 2015, 'Surface-modified electrodes in the mimicry of oxidative drug metabolism', TrAC-Trends in Analytical Chemistry, vol. 70, pp. 50-57. https://doi.org/10.1016/j.trac.2015.01.017

Standard

Surface-modified electrodes in the mimicry of oxidative drug metabolism. / Yuan, Tao; Permentier, Hjalmar; Bischoff, Rainer.

In: TrAC-Trends in Analytical Chemistry, Vol. 70, 01.07.2015, p. 50-57.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Yuan T, Permentier H, Bischoff R. Surface-modified electrodes in the mimicry of oxidative drug metabolism. TrAC-Trends in Analytical Chemistry. 2015 Jul 1;70:50-57. https://doi.org/10.1016/j.trac.2015.01.017


BibTeX

@article{7481ceb0367146c4861d8cdb76d369de,
title = "Surface-modified electrodes in the mimicry of oxidative drug metabolism",
abstract = "This review discusses different approaches that have been taken to mimic oxidative drug metabolism as executed by members of the Cytochrome P450 (CYP450) family of enzymes in humans. Non-modified electrodes can be used to produce some of the oxidative drug metabolites observed in vivo but their scope is rather limited. Modifying electrodes with simple cofactors in analogy to those observed in CYP450 but without the protein scaffold extends these possibilities and notably allows driving reactions following a CYP450-like mechanism. The review ends with approaches to immobilize CYP450s or analogs thereof on electrodes to mimic the in vivo drug metabolism fully. We discuss future perspectives with respect to the advantages and the disadvantages of each level of complexity and possible ways forward.",
keywords = "Carbon-based electrode Cytochrome P450 Electrochemistry Gold electrode Metalloporphyrin Modified electrode Oxidative drug metabolism Self-assembly monolayer Surface modification Surface-modified electrode",
author = "Tao Yuan and Hjalmar Permentier and Rainer Bischoff",
year = "2015",
month = jul,
day = "1",
doi = "10.1016/j.trac.2015.01.017",
language = "English",
volume = "70",
pages = "50--57",
journal = "TrAC-Trends in Analytical Chemistry",
issn = "0165-9936",
publisher = "ELSEVIER SCI LTD",

}

RIS

TY - JOUR

T1 - Surface-modified electrodes in the mimicry of oxidative drug metabolism

AU - Yuan, Tao

AU - Permentier, Hjalmar

AU - Bischoff, Rainer

PY - 2015/7/1

Y1 - 2015/7/1

N2 - This review discusses different approaches that have been taken to mimic oxidative drug metabolism as executed by members of the Cytochrome P450 (CYP450) family of enzymes in humans. Non-modified electrodes can be used to produce some of the oxidative drug metabolites observed in vivo but their scope is rather limited. Modifying electrodes with simple cofactors in analogy to those observed in CYP450 but without the protein scaffold extends these possibilities and notably allows driving reactions following a CYP450-like mechanism. The review ends with approaches to immobilize CYP450s or analogs thereof on electrodes to mimic the in vivo drug metabolism fully. We discuss future perspectives with respect to the advantages and the disadvantages of each level of complexity and possible ways forward.

AB - This review discusses different approaches that have been taken to mimic oxidative drug metabolism as executed by members of the Cytochrome P450 (CYP450) family of enzymes in humans. Non-modified electrodes can be used to produce some of the oxidative drug metabolites observed in vivo but their scope is rather limited. Modifying electrodes with simple cofactors in analogy to those observed in CYP450 but without the protein scaffold extends these possibilities and notably allows driving reactions following a CYP450-like mechanism. The review ends with approaches to immobilize CYP450s or analogs thereof on electrodes to mimic the in vivo drug metabolism fully. We discuss future perspectives with respect to the advantages and the disadvantages of each level of complexity and possible ways forward.

KW - Carbon-based electrode Cytochrome P450 Electrochemistry Gold electrode Metalloporphyrin Modified electrode Oxidative drug metabolism Self-assembly monolayer Surface modification Surface-modified electrode

U2 - 10.1016/j.trac.2015.01.017

DO - 10.1016/j.trac.2015.01.017

M3 - Article

VL - 70

SP - 50

EP - 57

JO - TrAC-Trends in Analytical Chemistry

JF - TrAC-Trends in Analytical Chemistry

SN - 0165-9936

ER -

ID: 21996596