Sulfur regulation of the sulfate transporter genes sutA and sutB in Penicillium chrysogenum

van de Kamp, M., Schuurs, T. A., Vos, A., van der Lende, T. R., Konings, W. N. & Driessen, A. J. M., Oct-2000, In : Applied and environmental microbiology. 66, 10, p. 4536-4538 3 p.

Research output: Contribution to journalArticleAcademicpeer-review

Penicillium chrysogenum uses sulfate as a source of sulfur for the biosynthesis of penicillin. Sulfate uptake and the mRNA levels of the sulfate transporter-encoding sutB and sutA genes are all reduced by high sulfate concentrations and are elevated by sulfate starvation. In a high-penicillin-yielding strain, sutB is effectively transcribed even in the presence of excess sulfate. This deregulation may facilitate the efficient incorporation of sulfur into cysteine and penicillin.
Original languageEnglish
Pages (from-to)4536-4538
Number of pages3
JournalApplied and environmental microbiology
Issue number10
Publication statusPublished - Oct-2000


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