Sulfur regulation of the sulfate transporter genes sutA and sutB in Penicillium chrysogenumvan de Kamp, M., Schuurs, T. A., Vos, A., van der Lende, T. R., Konings, W. N. & Driessen, A. J. M., Oct-2000, In : Applied and environmental microbiology. 66, 10, p. 4536-4538 3 p.
Research output: Contribution to journal › Article › Academic › peer-review
Penicillium chrysogenum uses sulfate as a source of sulfur for the biosynthesis of penicillin. Sulfate uptake and the mRNA levels of the sulfate transporter-encoding sutB and sutA genes are all reduced by high sulfate concentrations and are elevated by sulfate starvation. In a high-penicillin-yielding strain, sutB is effectively transcribed even in the presence of excess sulfate. This deregulation may facilitate the efficient incorporation of sulfur into cysteine and penicillin.
|Number of pages||3|
|Journal||Applied and environmental microbiology|
|Publication status||Published - Oct-2000|
- Filamentous fungi, Aspergillus nidulans, ATP sulfurylase, biosynthesis, cloning, assimilation, activation