Publication

Sulfur regulation of the sulfate transporter genes sutA and sutB in Penicillium chrysogenum

van de Kamp, M., Schuurs, T. A., Vos, A., van der Lende, T. R., Konings, W. N. & Driessen, A. J. M., Oct-2000, In : Applied and environmental microbiology. 66, 10, p. 4536-4538 3 p.

Research output: Contribution to journalArticleAcademicpeer-review

Penicillium chrysogenum uses sulfate as a source of sulfur for the biosynthesis of penicillin. Sulfate uptake and the mRNA levels of the sulfate transporter-encoding sutB and sutA genes are all reduced by high sulfate concentrations and are elevated by sulfate starvation. In a high-penicillin-yielding strain, sutB is effectively transcribed even in the presence of excess sulfate. This deregulation may facilitate the efficient incorporation of sulfur into cysteine and penicillin.
Original languageEnglish
Pages (from-to)4536-4538
Number of pages3
JournalApplied and environmental microbiology
Volume66
Issue number10
Publication statusPublished - Oct-2000

    Keywords

  • Filamentous fungi, Aspergillus nidulans, ATP sulfurylase, biosynthesis, cloning, assimilation, activation

ID: 30570580