Successful treatment of intractable visual hallucinations with 5-HT 2A antagonist ketanserin

Sommer, I. E. C., Kleijer, H., Visser, L. & van Laar, T., 27-Jun-2018, In : BMJ Case Reports. 2018, 3 p., 224340.

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  • Successful treatment of intractable visual hallucinations with 5-HT2A antagonist ketanserin

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Hallucinations, visual, auditory or in another sensory modality, often respond well to treatment in patients with schizophrenia. Some, however, do not and can be very chronic and debilitating. We present a patient with schizophrenia with intractable hallucinations despite state of the art care, including high-dose clozapine and transcranial magnetic stimulation. Based on the possible role of the 5-HT2A receptor in hallucinations, we treated her with the antihypertensive drug ketanserin, a 5-HT2A receptor antagonist.This significantly reduced her visual but not her auditory hallucinations, suggesting a possible role of the 5HT2A receptor in the pathophysiology of specifically visual hallucinations. This is the first time ketanserin has been described to successfully reduce visual hallucinations in a patient with schizophrenia.

Original languageEnglish
Article number224340
Number of pages3
JournalBMJ Case Reports
Publication statusPublished - 27-Jun-2018


  • Adult, Female, Hallucinations/drug therapy, Humans, Ketanserin/therapeutic use, Serotonin Antagonists/therapeutic use, Treatment Outcome

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