Publication

Subtyping late-life depression according to inflammatory and metabolic dysregulation: a prospective study

Kokkeler, K. J. E., Marijnissen, R. M., Wardenaar, K. J., Rhebergen, D., van den Brink, R. H. S., van der Mast, R. C. & Oude Voshaar, R. C., 3-Jul-2020, In : Psychological Medicine. p. 1-11 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Kokkeler, K. J. E., Marijnissen, R. M., Wardenaar, K. J., Rhebergen, D., van den Brink, R. H. S., van der Mast, R. C., & Oude Voshaar, R. C. (2020). Subtyping late-life depression according to inflammatory and metabolic dysregulation: a prospective study. Psychological Medicine, 1-11. https://doi.org/10.1017/S0033291720002159

Author

Kokkeler, K J E ; Marijnissen, R M ; Wardenaar, K J ; Rhebergen, D ; van den Brink, R H S ; van der Mast, R C ; Oude Voshaar, R C. / Subtyping late-life depression according to inflammatory and metabolic dysregulation : a prospective study. In: Psychological Medicine. 2020 ; pp. 1-11.

Harvard

Kokkeler, KJE, Marijnissen, RM, Wardenaar, KJ, Rhebergen, D, van den Brink, RHS, van der Mast, RC & Oude Voshaar, RC 2020, 'Subtyping late-life depression according to inflammatory and metabolic dysregulation: a prospective study', Psychological Medicine, pp. 1-11. https://doi.org/10.1017/S0033291720002159

Standard

Subtyping late-life depression according to inflammatory and metabolic dysregulation : a prospective study. / Kokkeler, K J E; Marijnissen, R M; Wardenaar, K J; Rhebergen, D; van den Brink, R H S; van der Mast, R C; Oude Voshaar, R C.

In: Psychological Medicine, 03.07.2020, p. 1-11.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Kokkeler KJE, Marijnissen RM, Wardenaar KJ, Rhebergen D, van den Brink RHS, van der Mast RC et al. Subtyping late-life depression according to inflammatory and metabolic dysregulation: a prospective study. Psychological Medicine. 2020 Jul 3;1-11. https://doi.org/10.1017/S0033291720002159


BibTeX

@article{7ab434015d94405f9ee96bf7b7afc789,
title = "Subtyping late-life depression according to inflammatory and metabolic dysregulation: a prospective study",
abstract = "BACKGROUND: Inflammation and metabolic dysregulation are age-related physiological changes and are associated with depressive disorder. We tried to identify subgroups of depressed older patients based on their metabolic-inflammatory profile and examined the course of depression for these subgroups.METHODS: This clinical cohort study was conducted in a sample of 364 depressed older (⩾60 years) patients according to DSM-IV criteria. Severity of depressive symptoms was monitored every 6 months and a formal diagnostic interview repeated at 2-year follow-up. Latent class analyses based on baseline metabolic and inflammatory biomarkers were performed. Adjusted for confounders, we compared remission of depression at 2-year follow-up between the metabolic-inflammatory subgroups with logistic regression and the course of depression severity over 2-years by linear mixed models.RESULTS: We identified a 'healthy' subgroup (n = 181, 49.7{\%}) and five subgroups characterized by different profiles of metabolic-inflammatory dysregulation. Compared to the healthy subgroup, patients in the subgroup with mild 'metabolic and inflammatory dysregulation' (n = 137, 37.6{\%}) had higher depressive symptom scores, a lower rate of improvement in the first year, and were less likely to be remitted after 2-years [OR 0.49 (95{\%} CI 0.26-0.91)]. The four smaller subgroups characterized by a more specific immune-inflammatory dysregulation profile did not differ from the two main subgroups regarding the course of depression.CONCLUSIONS: Nearly half of the patients with late-life depressions suffer from metabolic-inflammatory dysregulation, which is also associated with more severe depression and a worse prognosis. Future studies should examine whether these depressed older patients benefit from a metabolic-inflammatory targeted treatment.",
author = "Kokkeler, {K J E} and Marijnissen, {R M} and Wardenaar, {K J} and D Rhebergen and {van den Brink}, {R H S} and {van der Mast}, {R C} and {Oude Voshaar}, {R C}",
year = "2020",
month = "7",
day = "3",
doi = "10.1017/S0033291720002159",
language = "English",
pages = "1--11",
journal = "Psychological Medicine",
issn = "0033-2917",
publisher = "Cambridge University Press",

}

RIS

TY - JOUR

T1 - Subtyping late-life depression according to inflammatory and metabolic dysregulation

T2 - a prospective study

AU - Kokkeler, K J E

AU - Marijnissen, R M

AU - Wardenaar, K J

AU - Rhebergen, D

AU - van den Brink, R H S

AU - van der Mast, R C

AU - Oude Voshaar, R C

PY - 2020/7/3

Y1 - 2020/7/3

N2 - BACKGROUND: Inflammation and metabolic dysregulation are age-related physiological changes and are associated with depressive disorder. We tried to identify subgroups of depressed older patients based on their metabolic-inflammatory profile and examined the course of depression for these subgroups.METHODS: This clinical cohort study was conducted in a sample of 364 depressed older (⩾60 years) patients according to DSM-IV criteria. Severity of depressive symptoms was monitored every 6 months and a formal diagnostic interview repeated at 2-year follow-up. Latent class analyses based on baseline metabolic and inflammatory biomarkers were performed. Adjusted for confounders, we compared remission of depression at 2-year follow-up between the metabolic-inflammatory subgroups with logistic regression and the course of depression severity over 2-years by linear mixed models.RESULTS: We identified a 'healthy' subgroup (n = 181, 49.7%) and five subgroups characterized by different profiles of metabolic-inflammatory dysregulation. Compared to the healthy subgroup, patients in the subgroup with mild 'metabolic and inflammatory dysregulation' (n = 137, 37.6%) had higher depressive symptom scores, a lower rate of improvement in the first year, and were less likely to be remitted after 2-years [OR 0.49 (95% CI 0.26-0.91)]. The four smaller subgroups characterized by a more specific immune-inflammatory dysregulation profile did not differ from the two main subgroups regarding the course of depression.CONCLUSIONS: Nearly half of the patients with late-life depressions suffer from metabolic-inflammatory dysregulation, which is also associated with more severe depression and a worse prognosis. Future studies should examine whether these depressed older patients benefit from a metabolic-inflammatory targeted treatment.

AB - BACKGROUND: Inflammation and metabolic dysregulation are age-related physiological changes and are associated with depressive disorder. We tried to identify subgroups of depressed older patients based on their metabolic-inflammatory profile and examined the course of depression for these subgroups.METHODS: This clinical cohort study was conducted in a sample of 364 depressed older (⩾60 years) patients according to DSM-IV criteria. Severity of depressive symptoms was monitored every 6 months and a formal diagnostic interview repeated at 2-year follow-up. Latent class analyses based on baseline metabolic and inflammatory biomarkers were performed. Adjusted for confounders, we compared remission of depression at 2-year follow-up between the metabolic-inflammatory subgroups with logistic regression and the course of depression severity over 2-years by linear mixed models.RESULTS: We identified a 'healthy' subgroup (n = 181, 49.7%) and five subgroups characterized by different profiles of metabolic-inflammatory dysregulation. Compared to the healthy subgroup, patients in the subgroup with mild 'metabolic and inflammatory dysregulation' (n = 137, 37.6%) had higher depressive symptom scores, a lower rate of improvement in the first year, and were less likely to be remitted after 2-years [OR 0.49 (95% CI 0.26-0.91)]. The four smaller subgroups characterized by a more specific immune-inflammatory dysregulation profile did not differ from the two main subgroups regarding the course of depression.CONCLUSIONS: Nearly half of the patients with late-life depressions suffer from metabolic-inflammatory dysregulation, which is also associated with more severe depression and a worse prognosis. Future studies should examine whether these depressed older patients benefit from a metabolic-inflammatory targeted treatment.

U2 - 10.1017/S0033291720002159

DO - 10.1017/S0033291720002159

M3 - Article

C2 - 32618234

SP - 1

EP - 11

JO - Psychological Medicine

JF - Psychological Medicine

SN - 0033-2917

ER -

ID: 128819607