Publication

Studying the gut virome in the metagenomic era: challenges and perspectives

Garmaeva, S., Sinha, T., Kurilshikov, A., Wijmenga, C., Fu, J. & Zhernakova, S., 28-Oct-2019, In : BMC Biology. 17, 1, 14 p., 84.

Research output: Contribution to journalReview articleAcademicpeer-review

The human gut harbors a complex ecosystem of microorganisms, including bacteria and viruses. With the rise of next-generation sequencing technologies, we have seen a quantum leap in the study of humangut-inhabiting bacteria, yet the viruses that infect these bacteria, known as bacteriophages, remain underexplored. In this review, we focus on what is known about the role of bacteriophages in human health and the technical challenges involved in studying the gut virome, of which they are a major component. Lastly, we discuss what can be learned from studies of bacteriophages in other ecosystems.

Original languageEnglish
Article number84
Number of pages14
JournalBMC Biology
Volume17
Issue number1
Publication statusPublished - 28-Oct-2019

    Keywords

  • VIRUS-LIKE PARTICLES, BACTERIOPHAGE-LAMBDA, BACTERIAL MICROBIOME, FECAL MICROBIOTA, MARINE VIRUSES, PHAGE, EVOLUTION, DYNAMICS, GENOMES, PROPHAGES

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