Studying cancer metastasis: Existing models, challenges and future perspectivesvan Marion, D. M. S., Domanska, U. M., Timmer-Bosscha, H. & Walenkamp, A. M. E., Jan-2016, In : Critical Reviews in Oncology/Hematology. 97, p. 107-117 11 p.
Research output: Contribution to journal › Review article › Academic › peer-review
Cancer metastasis causes most cancer-related deaths. Several model systems to study the complex and multi step process of metastasis exist, including in vitro systems, ex-vivo organ slices, Drosophila Melanogaster and zebrafish models and the use of the chorio allantoic membrane (CAM) of fertilized chicken eggs. These models are relatively easy and cheap but often lack the opportunity to study the complete metastasis cascade. More complex but also more expensive is the use of animal models including the more recently developed patient derived tumor xenografts (PDTX). In this review, we give an overview of the existing metastatic models, discuss the challenges of improving current models to enhance translation from the preclinical to the clinical setting and consider future perspectives. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
|Number of pages||11|
|Journal||Critical Reviews in Oncology/Hematology|
|Publication status||Published - Jan-2016|
- Cancer, Metastasis, Animal model, In vitro model, In silico model, Patient derived (tumor) xenograft model, Humanized mouse models, MATRIX-METALLOPROTEINASE INHIBITOR, PATIENT-DERIVED XENOGRAFTS, ADVANCED BREAST-CANCER, CELL LUNG-CANCER, EMBRYO CHORIOALLANTOIC MEMBRANE, RANDOMIZED PHASE-III, IN-VIVO, PANCREATIC-CANCER, OVARIAN-CANCER, MOUSE MODELS