Publication

Study protocol of validating a numerical model to assess the blood flow in the circle of Willis

Shen, Y., Wei, Y., Bokkers, R. P. H., Uyttenboogaart, M. & van Dijk, J. M. C., 4-Jun-2020, In : BMJ Open. 10, 6, 6 p., 036404.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Shen, Y., Wei, Y., Bokkers, R. P. H., Uyttenboogaart, M., & van Dijk, J. M. C. (2020). Study protocol of validating a numerical model to assess the blood flow in the circle of Willis. BMJ Open, 10(6), [036404]. https://doi.org/10.1136/bmjopen-2019-036404

Author

Shen, Yuanyuan ; Wei, Yanji ; Bokkers, Reinoud P H ; Uyttenboogaart, Maarten ; van Dijk, J Marc C. / Study protocol of validating a numerical model to assess the blood flow in the circle of Willis. In: BMJ Open. 2020 ; Vol. 10, No. 6.

Harvard

Shen, Y, Wei, Y, Bokkers, RPH, Uyttenboogaart, M & van Dijk, JMC 2020, 'Study protocol of validating a numerical model to assess the blood flow in the circle of Willis', BMJ Open, vol. 10, no. 6, 036404. https://doi.org/10.1136/bmjopen-2019-036404

Standard

Study protocol of validating a numerical model to assess the blood flow in the circle of Willis. / Shen, Yuanyuan; Wei, Yanji; Bokkers, Reinoud P H; Uyttenboogaart, Maarten; van Dijk, J Marc C.

In: BMJ Open, Vol. 10, No. 6, 036404, 04.06.2020.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Shen Y, Wei Y, Bokkers RPH, Uyttenboogaart M, van Dijk JMC. Study protocol of validating a numerical model to assess the blood flow in the circle of Willis. BMJ Open. 2020 Jun 4;10(6). 036404. https://doi.org/10.1136/bmjopen-2019-036404


BibTeX

@article{01cbcb5a3bd8433a9bdcd0ebf7252ceb,
title = "Study protocol of validating a numerical model to assess the blood flow in the circle of Willis",
abstract = "Introduction We developed a zero-dimensional (0D) model to assess the patient-specific haemodynamics in the circle of Willis (CoW). Similar numerical models for simulating the cerebral blood flow (CBF) had only been validated qualitatively in healthy volunteers by magnetic resonance (MR) angiography and transcranial Doppler (TCD). This study aims to validate whether a numerical model can simulate patient-specific blood flow in the CoW under pathological conditions.Methods and analysis This study is a diagnostic accuracy study. We aim to collect data from a previously performed prospective study that involved patients with aneurysmal subarachnoid haemorrhage (aSAH) receiving both TCD and brain Computerd Tomography angiography (CTA) at the same day. The cerebral flow velocities are calculated by the 0D model, based on the vessel diameters measured on the CTA of each patient. In this study, TCD is considered the gold standard for measuring flow velocity in the CoW. The agreement will be analysed using Pearson correlation coefficients.Ethics and dissemination This study protocol has been approved by the Medical Ethics Review Board of the University Medical Center Groningen: METc2019/103. The results will be submitted to an international scientific journal for peer-reviewed publication.Trial registration number NL8114.",
keywords = "stroke, neurosurgery, neuroradiology",
author = "Yuanyuan Shen and Yanji Wei and Bokkers, {Reinoud P H} and Maarten Uyttenboogaart and {van Dijk}, {J Marc C}",
note = "{\circledC} Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ.",
year = "2020",
month = "6",
day = "4",
doi = "10.1136/bmjopen-2019-036404",
language = "English",
volume = "10",
journal = "BMJ Open",
issn = "2044-6055",
publisher = "BMJ PUBLISHING GROUP",
number = "6",

}

RIS

TY - JOUR

T1 - Study protocol of validating a numerical model to assess the blood flow in the circle of Willis

AU - Shen, Yuanyuan

AU - Wei, Yanji

AU - Bokkers, Reinoud P H

AU - Uyttenboogaart, Maarten

AU - van Dijk, J Marc C

N1 - © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ.

PY - 2020/6/4

Y1 - 2020/6/4

N2 - Introduction We developed a zero-dimensional (0D) model to assess the patient-specific haemodynamics in the circle of Willis (CoW). Similar numerical models for simulating the cerebral blood flow (CBF) had only been validated qualitatively in healthy volunteers by magnetic resonance (MR) angiography and transcranial Doppler (TCD). This study aims to validate whether a numerical model can simulate patient-specific blood flow in the CoW under pathological conditions.Methods and analysis This study is a diagnostic accuracy study. We aim to collect data from a previously performed prospective study that involved patients with aneurysmal subarachnoid haemorrhage (aSAH) receiving both TCD and brain Computerd Tomography angiography (CTA) at the same day. The cerebral flow velocities are calculated by the 0D model, based on the vessel diameters measured on the CTA of each patient. In this study, TCD is considered the gold standard for measuring flow velocity in the CoW. The agreement will be analysed using Pearson correlation coefficients.Ethics and dissemination This study protocol has been approved by the Medical Ethics Review Board of the University Medical Center Groningen: METc2019/103. The results will be submitted to an international scientific journal for peer-reviewed publication.Trial registration number NL8114.

AB - Introduction We developed a zero-dimensional (0D) model to assess the patient-specific haemodynamics in the circle of Willis (CoW). Similar numerical models for simulating the cerebral blood flow (CBF) had only been validated qualitatively in healthy volunteers by magnetic resonance (MR) angiography and transcranial Doppler (TCD). This study aims to validate whether a numerical model can simulate patient-specific blood flow in the CoW under pathological conditions.Methods and analysis This study is a diagnostic accuracy study. We aim to collect data from a previously performed prospective study that involved patients with aneurysmal subarachnoid haemorrhage (aSAH) receiving both TCD and brain Computerd Tomography angiography (CTA) at the same day. The cerebral flow velocities are calculated by the 0D model, based on the vessel diameters measured on the CTA of each patient. In this study, TCD is considered the gold standard for measuring flow velocity in the CoW. The agreement will be analysed using Pearson correlation coefficients.Ethics and dissemination This study protocol has been approved by the Medical Ethics Review Board of the University Medical Center Groningen: METc2019/103. The results will be submitted to an international scientific journal for peer-reviewed publication.Trial registration number NL8114.

KW - stroke

KW - neurosurgery

KW - neuroradiology

U2 - 10.1136/bmjopen-2019-036404

DO - 10.1136/bmjopen-2019-036404

M3 - Article

C2 - 32503872

VL - 10

JO - BMJ Open

JF - BMJ Open

SN - 2044-6055

IS - 6

M1 - 036404

ER -

ID: 127279133