Structure and pharmacological studies of the anaesthetic 1-(3-n-butoxypropyl)-4-benzoyloxypiperidin hydrochloride and its complex with beta-cyclodextrin in solution. NMR and IR-spectroscopy data

Kemelbekov, U., Saipov, A., Abdildanova, A., Ospanov, I., Luo, Y., Guskov, A., Saenger, W., Imachova, S., Nasyrova, S. & Pichkhadze, G., Dec-2013, In : Journal of inclusion phenomena and macrocyclic chemistry. 77, 1-4, p. 249-257 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

  • U. Kemelbekov
  • A. Saipov
  • A. Abdildanova
  • I. Ospanov
  • Y. Luo
  • A. Guskov
  • W. Saenger
  • Sh. Imachova
  • S. Nasyrova
  • G. Pichkhadze

Using different 1D and 2D NMR methods including Nuclear Overhauser effects in the rotating frame the structural features of 1-(3-n-butoxypropyl)-4-benzoyloxypiperidine hydrochloride and its inclusion complex with beta-cyclodextrin were investigated in aqueous solution. 1-(3-n-butoxypropyl)-4-benzoyloxypiperidine hydrochloride exists as a mixture of two conformational isomers with axial and equatorial orientation of the benzoyloxy group (ca. 2:1). Both these isomers effectively form inclusion complexes with beta-cyclodextrin as host molecule.

Original languageEnglish
Pages (from-to)249-257
Number of pages9
JournalJournal of inclusion phenomena and macrocyclic chemistry
Issue number1-4
Publication statusPublished - Dec-2013
Externally publishedYes


  • 1-(3-n-Butoxypropyl)-4-benzoyloxypiperidine hydrochloride, Cyclodextrin, Anaesthetic, 1D and 2D NMR-spectroscopy

ID: 12736824