Structure and pharmacological studies of the anaesthetic 1-(3-n-butoxypropyl)-4-benzoyloxypiperidin hydrochloride and its complex with beta-cyclodextrin in solution. NMR and IR-spectroscopy dataKemelbekov, U., Saipov, A., Abdildanova, A., Ospanov, I., Luo, Y., Guskov, A., Saenger, W., Imachova, S., Nasyrova, S. & Pichkhadze, G., Dec-2013, In : Journal of inclusion phenomena and macrocyclic chemistry. 77, 1-4, p. 249-257 9 p.
Research output: Contribution to journal › Article › Academic › peer-review
Using different 1D and 2D NMR methods including Nuclear Overhauser effects in the rotating frame the structural features of 1-(3-n-butoxypropyl)-4-benzoyloxypiperidine hydrochloride and its inclusion complex with beta-cyclodextrin were investigated in aqueous solution. 1-(3-n-butoxypropyl)-4-benzoyloxypiperidine hydrochloride exists as a mixture of two conformational isomers with axial and equatorial orientation of the benzoyloxy group (ca. 2:1). Both these isomers effectively form inclusion complexes with beta-cyclodextrin as host molecule.
|Number of pages||9|
|Journal||Journal of inclusion phenomena and macrocyclic chemistry|
|Publication status||Published - Dec-2013|
- 1-(3-n-Butoxypropyl)-4-benzoyloxypiperidine hydrochloride, Cyclodextrin, Anaesthetic, 1D and 2D NMR-spectroscopy