Publication

STRUCTURAL CHANGES OF THE HEART DURING SEVERE SEPSIS OR SEPTIC SHOCK

Smeding, L., Plotz, F. B., Groeneveld, A. B. J. & Kneyber, M. C. J., May-2012, In : Shock. 37, 5, p. 449-456 8 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Cardiovascular dysfunction is common in severe sepsis or septic shock. Although functional alterations are often described, the elevated serum levels of cardiac proteins and autopsy findings of myocardial immune cell infiltration, edema, and damaged mitochondria suggest that structural changes to the heart during severe sepsis and septic shock may occur and may contribute to cardiac dysfunction. We explored the available literature on structural (versus functional) cardiac alterations during experimental and human endotoxemia and/or sepsis. Limited data suggest that the structural changes could be prevented, and myocardial function improved by (pre-)treatment with platelet-activating factor, cyclosporin A, glutamine, caffeine, simvastatin, or caspase inhibitors.

Original languageEnglish
Pages (from-to)449-456
Number of pages8
JournalShock
Volume37
Issue number5
Publication statusPublished - May-2012

    Keywords

  • Sepsis, heart failure, edema, inflammation, apoptosis, mitochondria, INDUCED MYOCARDIAL DYSFUNCTION, GLYCATION END-PRODUCTS, MITOCHONDRIAL PERMEABILITY TRANSITION, INDUCED CARDIAC DYSFUNCTION, ESCHERICHIA-COLI HEMOLYSIN, MULTIPLE ORGAN DYSFUNCTION, CANINE ENDOTOXIN-SHOCK, NECROSIS-FACTOR-ALPHA, CYTOCHROME-C-OXIDASE, CELL-DEATH

ID: 5548162