Strategies employed by viruses to manipulate autophagy

Dinesh Kumar, N., Smit, J. M. & Reggiori, F., 2020, Progress in Molecular Biology and Translational Science. Elsevier, Vol. 172. p. 203-237 35 p. (Progress in molecular biology and translational science).

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Autophagy, originally described as a conserved bulk degradation pathway important to maintain cellular homeostasis during starvation, has also been implicated in playing a central role in multiple physiological processes. For example, autophagy is part of our innate immunity by targeting intracellular pathogens to lysosomes for degradation in a process called xenophagy. Coevolution and adaptation between viruses and autophagy have armed viruses with a multitude of strategies to counteract the antiviral functions of the autophagy pathway. In addition, some viruses have acquired mechanisms to exploit specific functions of either autophagy or the key components of this process, the autophagy-related (ATG) proteins, to promote viral replication and pathogenesis. In this chapter, we describe several examples where the strategy employed by a virus to subvert autophagy has been described with molecular detail. Their stratagems positively or negatively target practically all the steps of autophagy, including the signaling pathways regulating this process. This highlights the intricate relationship between autophagy and viruses and how by commandeering autophagy, viruses have devised ways to fine-tune their replication.

Original languageEnglish
Title of host publicationProgress in Molecular Biology and Translational Science
Number of pages35
Publication statusPublished - 2020

Publication series

NameProgress in molecular biology and translational science
ISSN (Print)1877-1173

ID: 128948635