Publication

Status of cellular immunity lacks prognostic significance in vulvar squamous carcinoma

de Jong, R. A., Toppen, N. L., ten Hoor, K. A., Boezen, H. M., Kema, I. P., Hollema, H. & Nijman, H. W., Apr-2012, In : Gynecologic Oncology. 125, 1, p. 186-193 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

de Jong, R. A., Toppen, N. L., ten Hoor, K. A., Boezen, H. M., Kema, I. P., Hollema, H., & Nijman, H. W. (2012). Status of cellular immunity lacks prognostic significance in vulvar squamous carcinoma. Gynecologic Oncology, 125(1), 186-193. https://doi.org/10.1016/j.ygyno.2011.12.416

Author

de Jong, R.A. ; Toppen, N. L. ; ten Hoor, K. A. ; Boezen, H. M. ; Kema, I. P. ; Hollema, H. ; Nijman, H. W. / Status of cellular immunity lacks prognostic significance in vulvar squamous carcinoma. In: Gynecologic Oncology. 2012 ; Vol. 125, No. 1. pp. 186-193.

Harvard

de Jong, RA, Toppen, NL, ten Hoor, KA, Boezen, HM, Kema, IP, Hollema, H & Nijman, HW 2012, 'Status of cellular immunity lacks prognostic significance in vulvar squamous carcinoma', Gynecologic Oncology, vol. 125, no. 1, pp. 186-193. https://doi.org/10.1016/j.ygyno.2011.12.416

Standard

Status of cellular immunity lacks prognostic significance in vulvar squamous carcinoma. / de Jong, R.A.; Toppen, N. L.; ten Hoor, K. A.; Boezen, H. M.; Kema, I. P.; Hollema, H.; Nijman, H. W.

In: Gynecologic Oncology, Vol. 125, No. 1, 04.2012, p. 186-193.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

de Jong RA, Toppen NL, ten Hoor KA, Boezen HM, Kema IP, Hollema H et al. Status of cellular immunity lacks prognostic significance in vulvar squamous carcinoma. Gynecologic Oncology. 2012 Apr;125(1):186-193. https://doi.org/10.1016/j.ygyno.2011.12.416


BibTeX

@article{79c1813886ce4ddcb023fc73826215b4,
title = "Status of cellular immunity lacks prognostic significance in vulvar squamous carcinoma",
abstract = "Objective. It is generally recognized that the immune system has an important role in regulating cancer development. Evidence indicating a prognostic role of the immune system in vulvar carcinoma is scarce. This study investigated the presence and prognostic significance of several aspects of the immune system in vulvar squamous carcinoma.Methods. The number of intratumoral CD8(+) and Foxp3(+) T-lymphocytes, next to HLA class I (HLA-A, HLA-B/C and beta(2)-m) and indoleamine 2,3-dioxygenase (IDO) expression was determined by immunohistochemistry in a consecutively selected cohort of 286 vulvar squamous carcinoma patients, all treated in the University Medical Center Groningen, the Netherlands. Associations between immunohistochemistry expression and the influence on survival were determined.Results. The number of tumor-infiltrating CD8(+) T-lymphocytes was significantly lower in tumors with loss of HLA-A (p=0.004), HLA-B/C (p=0.024) or beta(2)-m (p=0.025) expression compared with tumors with expression of HLA class I. No association was found between the number of intratumoral CD8(+) T-lymphocytes and Foxp3(+) T-lymphocytes, HLA class I and IDO expression and survival of vulvar squamous carcinoma patients.Conclusion. Our results indicate that the immune system does not seem to have a major influence on prognosis of patients with vulvar squamous carcinoma. (C) 2011 Elsevier Inc. All rights reserved.",
keywords = "Vulvar carcinoma, T-lymphocytes, HLA class I, Indoleamine 2,3-dioxygenase, REGULATORY T-CELLS, TUMOR-INFILTRATING LYMPHOCYTES, STAGE OVARIAN-CANCER, ANTIGEN CLASS-I, INDOLEAMINE 2,3-DIOXYGENASE, ENDOMETRIAL CANCER, EXPRESSION, SURVIVAL, NESTS, ASSOCIATION",
author = "{de Jong}, R.A. and Toppen, {N. L.} and {ten Hoor}, {K. A.} and Boezen, {H. M.} and Kema, {I. P.} and H. Hollema and Nijman, {H. W.}",
note = "Copyright {\^A}{\textcopyright} 2011 Elsevier Inc. All rights reserved.",
year = "2012",
month = apr,
doi = "10.1016/j.ygyno.2011.12.416",
language = "English",
volume = "125",
pages = "186--193",
journal = "Gynecologic Oncology",
issn = "0090-8258",
publisher = "ACADEMIC PRESS INC ELSEVIER SCIENCE",
number = "1",

}

RIS

TY - JOUR

T1 - Status of cellular immunity lacks prognostic significance in vulvar squamous carcinoma

AU - de Jong, R.A.

AU - Toppen, N. L.

AU - ten Hoor, K. A.

AU - Boezen, H. M.

AU - Kema, I. P.

AU - Hollema, H.

AU - Nijman, H. W.

N1 - Copyright © 2011 Elsevier Inc. All rights reserved.

PY - 2012/4

Y1 - 2012/4

N2 - Objective. It is generally recognized that the immune system has an important role in regulating cancer development. Evidence indicating a prognostic role of the immune system in vulvar carcinoma is scarce. This study investigated the presence and prognostic significance of several aspects of the immune system in vulvar squamous carcinoma.Methods. The number of intratumoral CD8(+) and Foxp3(+) T-lymphocytes, next to HLA class I (HLA-A, HLA-B/C and beta(2)-m) and indoleamine 2,3-dioxygenase (IDO) expression was determined by immunohistochemistry in a consecutively selected cohort of 286 vulvar squamous carcinoma patients, all treated in the University Medical Center Groningen, the Netherlands. Associations between immunohistochemistry expression and the influence on survival were determined.Results. The number of tumor-infiltrating CD8(+) T-lymphocytes was significantly lower in tumors with loss of HLA-A (p=0.004), HLA-B/C (p=0.024) or beta(2)-m (p=0.025) expression compared with tumors with expression of HLA class I. No association was found between the number of intratumoral CD8(+) T-lymphocytes and Foxp3(+) T-lymphocytes, HLA class I and IDO expression and survival of vulvar squamous carcinoma patients.Conclusion. Our results indicate that the immune system does not seem to have a major influence on prognosis of patients with vulvar squamous carcinoma. (C) 2011 Elsevier Inc. All rights reserved.

AB - Objective. It is generally recognized that the immune system has an important role in regulating cancer development. Evidence indicating a prognostic role of the immune system in vulvar carcinoma is scarce. This study investigated the presence and prognostic significance of several aspects of the immune system in vulvar squamous carcinoma.Methods. The number of intratumoral CD8(+) and Foxp3(+) T-lymphocytes, next to HLA class I (HLA-A, HLA-B/C and beta(2)-m) and indoleamine 2,3-dioxygenase (IDO) expression was determined by immunohistochemistry in a consecutively selected cohort of 286 vulvar squamous carcinoma patients, all treated in the University Medical Center Groningen, the Netherlands. Associations between immunohistochemistry expression and the influence on survival were determined.Results. The number of tumor-infiltrating CD8(+) T-lymphocytes was significantly lower in tumors with loss of HLA-A (p=0.004), HLA-B/C (p=0.024) or beta(2)-m (p=0.025) expression compared with tumors with expression of HLA class I. No association was found between the number of intratumoral CD8(+) T-lymphocytes and Foxp3(+) T-lymphocytes, HLA class I and IDO expression and survival of vulvar squamous carcinoma patients.Conclusion. Our results indicate that the immune system does not seem to have a major influence on prognosis of patients with vulvar squamous carcinoma. (C) 2011 Elsevier Inc. All rights reserved.

KW - Vulvar carcinoma

KW - T-lymphocytes

KW - HLA class I

KW - Indoleamine 2,3-dioxygenase

KW - REGULATORY T-CELLS

KW - TUMOR-INFILTRATING LYMPHOCYTES

KW - STAGE OVARIAN-CANCER

KW - ANTIGEN CLASS-I

KW - INDOLEAMINE 2,3-DIOXYGENASE

KW - ENDOMETRIAL CANCER

KW - EXPRESSION

KW - SURVIVAL

KW - NESTS

KW - ASSOCIATION

U2 - 10.1016/j.ygyno.2011.12.416

DO - 10.1016/j.ygyno.2011.12.416

M3 - Article

C2 - 22155674

VL - 125

SP - 186

EP - 193

JO - Gynecologic Oncology

JF - Gynecologic Oncology

SN - 0090-8258

IS - 1

ER -

ID: 5527535