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Status of cellular immunity lacks prognostic significance in vulvar squamous carcinoma

de Jong, R. A., Toppen, N. L., ten Hoor, K. A., Boezen, H. M., Kema, I. P., Hollema, H. & Nijman, H. W., Apr-2012, In : Gynecologic Oncology. 125, 1, p. 186-193 8 p.

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Objective. It is generally recognized that the immune system has an important role in regulating cancer development. Evidence indicating a prognostic role of the immune system in vulvar carcinoma is scarce. This study investigated the presence and prognostic significance of several aspects of the immune system in vulvar squamous carcinoma.

Methods. The number of intratumoral CD8(+) and Foxp3(+) T-lymphocytes, next to HLA class I (HLA-A, HLA-B/C and beta(2)-m) and indoleamine 2,3-dioxygenase (IDO) expression was determined by immunohistochemistry in a consecutively selected cohort of 286 vulvar squamous carcinoma patients, all treated in the University Medical Center Groningen, the Netherlands. Associations between immunohistochemistry expression and the influence on survival were determined.

Results. The number of tumor-infiltrating CD8(+) T-lymphocytes was significantly lower in tumors with loss of HLA-A (p=0.004), HLA-B/C (p=0.024) or beta(2)-m (p=0.025) expression compared with tumors with expression of HLA class I. No association was found between the number of intratumoral CD8(+) T-lymphocytes and Foxp3(+) T-lymphocytes, HLA class I and IDO expression and survival of vulvar squamous carcinoma patients.

Conclusion. Our results indicate that the immune system does not seem to have a major influence on prognosis of patients with vulvar squamous carcinoma. (C) 2011 Elsevier Inc. All rights reserved.

Original languageEnglish
Pages (from-to)186-193
Number of pages8
JournalGynecologic Oncology
Volume125
Issue number1
Publication statusPublished - Apr-2012

    Keywords

  • Vulvar carcinoma, T-lymphocytes, HLA class I, Indoleamine 2,3-dioxygenase, REGULATORY T-CELLS, TUMOR-INFILTRATING LYMPHOCYTES, STAGE OVARIAN-CANCER, ANTIGEN CLASS-I, INDOLEAMINE 2,3-DIOXYGENASE, ENDOMETRIAL CANCER, EXPRESSION, SURVIVAL, NESTS, ASSOCIATION

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