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Statin use in patients with nephrotic syndrome is associated with a lower risk of venous thromboembolism

Resh, M., Mahmoodi, B. K., Navis, G. J., Veeger, N. J. G. M. & Lijfering, W. M., May-2011, In : Thrombosis Research. 127, 5, p. 395-399 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Background: Nephrotic syndrome (NS) is a well-known risk factor for venous thromboembolism (VTE), however preventive measures are not routinely taken. In non-renal populations, statins are associated with lower risk of VTE. Hence, we set up this single-center retrospective cohort study to assess whether statin use influenced VTE risk in NS subjects.

Methods: We analyzed 289 consecutive patients with NS (defined by proteinuria >= 3.5 g/day) who were aged >18 years at the study entry and followed for at least 6 months. Use of statins and concomitant medication were determined.

Results: Of patients with NS (59% men; mean age, 42 years), 48% used statins for at least 1 month during NS. Using univariate and time-dependent Cox regression analyses, hazard ratio for VTE in statin users versus non-users was 0.2 (95% CI, 0.1-0.7) and 0.6 (95% CI, 0.2 -2.0), respectively. Adjustments for potential confounders did not change outcomes. Three VTE events occurred in a total of 812 statin-years, corresponding to an annual incidence of 0.37% (95% CI, 0.12-1.15). In contrast, 17 VTE occurred in a total of 2106 patient-years without statin exposure, annual incidence 0.81% (95% CI, 0.50-1.30).

Conclusions: Although statistically significant, the hazard ratio of 0.2 for VTE risk in statin users versus non-users could have been biased, but the time-dependent hazard ratio of 0.6 was probably not. As the association was in the same direction for both analyses, we conclude that statin use is associated with a lower risk of VTE in patients with NS. (C) 2011 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)395-399
Number of pages5
JournalThrombosis Research
Volume127
Issue number5
Publication statusPublished - May-2011

    Keywords

  • Statins, Nephrotic syndrome, Venous thrombosis, COA REDUCTASE INHIBITORS, DEEP-VEIN THROMBOSIS, RANDOMIZED-TRIAL, METAANALYSIS, THERAPY, DISEASE, COMPLICATIONS, PREVENTION, MANAGEMENT, EVENTS

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