Statin Use and Functional Outcome after Tissue Plasminogen Activator Treatment in Acute Ischaemic Stroke

Miedema, I., Uyttenboogaart, M., Koopman, K., De Keyser, J. & Luijckx, G. J., Feb-2010, In : Cerebrovascular Diseases. 29, 3, p. 263-267 5 p.

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Background: Preliminary findings suggest that statins may have a neuroprotective effect in patients with acute ischaemic stroke. This study investigated whether patients prior on statin therapy and treated with tissue plasminogen activator (tPA) for acute ischaemic stroke have a better functional outcome than statin-naive patients. Methods: In a prospective observational cohort study of 476 acute ischaemic stroke patients treated with tPA we investigated the relationship between prior statin use and functional outcome at 3 months, the occurrence of symptomatic intracerebral haemorrhage (SICH) and early in-hospital mortality. Ischaemic stroke subtypes were defined according to the TOAST classification. Favourable outcome was defined as a modified Rankin Scale score

Original languageEnglish
Pages (from-to)263-267
Number of pages5
JournalCerebrovascular Diseases
Issue number3
Publication statusPublished - Feb-2010


  • Acute ischaemic stroke, Statins, Tissue plasminogen activator, THROMBOLYSIS, REDUCTION, PRETREATMENT, PREVENTION, SUBTYPES, EVENTS, TRIAL

ID: 5021950