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Statin Use and Cognitive Function: Population-Based Observational Study with Long-Term Follow-Up

Joosten, H., Visser, S. T., van Eersel, M. E., Gansevoort, R. T., Bilo, H. J. G., Slaets, J. P. & Izaks, G. J., 26-Dec-2014, In : PLoS ONE. 9, 12, 15 p., e115755.

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We aimed to evaluate the association between statin use and cognitive function. Cognitive function was measured with the Ruff Figural Fluency Test (RFFT; worst score, 0; best score, 175 points) and the Visual Association Test (VAT; low performance, 0-10; high performance, 11-12 points) in an observational study that included 4,095 community-dwelling participants aged 35-82 years. Data on statin use were obtained from a computerized pharmacy database. Analysis were done for the total cohort and subsamples matched on cardiovascular risk (N=1232) or propensity score for statin use (N=3609). We found that a total of 904 participants (10%) used a statin. Statin users were older than non-users: mean age (SD) 61 (10) vs. 52 (11) years (p

Original languageEnglish
Article numbere115755
Number of pages15
JournalPLoS ONE
Volume9
Issue number12
Publication statusPublished - 26-Dec-2014

    Keywords

  • CARDIOVASCULAR RISK PROFILE, OLDER-ADULTS, LATE-LIFE, DEMENTIA, DISEASE, IMPAIRMENT, CHOLESTEROL, PREVENTION
Related Publications
  1. Correction: Statin Use and Cognitive Function: Population-Based Observational Study with Long-Term Follow-Up (vol 9, e115755, 2014)

    Joosten, H., Visser, S. T., van Eersel, M. E., Gansevoort, R. T. & Bilo, H. J. G., 6-Feb-2015, In : PLoS ONE. 10, 2, 1 p., e0118045.

    Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

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  1. Data from: Statin use and cognitive function: population-based observational study with long-term follow-up

    Joosten, J. (Creator), Visser, S. (Creator), Eersel, van, M. (Creator), Gansevoort, R. (Creator), Bilo, H. (Creator), Slaets, J. (Creator), Izaks, G. J. (Creator), University of Groningen, 3-Jan-2015

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