Publication

Stage-dependent detection of CD14(+) and CD16(+) cells in the human heart after myocardial infarction

Czepluch, F. S., Schlegel, M., Bremmer, F., Behnes, C. L., Hasenfuss, G. & Schaefer, K., Sep-2013, In : Virchows Archiv. 463, 3, p. 459-469 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

  • Frauke S. Czepluch
  • Magdalena Schlegel
  • Felix Bremmer
  • Carl L. Behnes
  • Gerd Hasenfuss
  • Katrin Schaefer

Monocytes are critically involved in cardiovascular wound healing processes. Human monocytes can be classified into two subsets based on the expression of CD14 and CD16. Here, we examined the temporal and spatial distribution of CD14(+) and CD16(+) cells after myocardial infarction (MI) in human heart and spleen tissue and correlated it with markers of cardiac repair. Heart samples obtained at autopsy were histologically classified into acute (AMI; n=11), subacute (SAMI; n=10) and old (OMI; n=16) MI, or control myocardium (CONTR; n=8). Histochemical analyses revealed marked fibrosis in OMI (p

Original languageEnglish
Pages (from-to)459-469
Number of pages11
JournalVirchows Archiv
Volume463
Issue number3
Publication statusPublished - Sep-2013

    Keywords

  • CD14, CD16, Cardiac wound healing, Monocytes, Myocardial infarction, Spleen, HUMAN PERIPHERAL-BLOOD, MONOCYTE SUBSETS, ADHESION MOLECULE, HETEROGENEITY, OSTEOPONTIN, EXPRESSION, INJURY, ATHEROSCLEROSIS, IDENTIFICATION, ISCHEMIA

ID: 5947186