Publication

SPECT and PET in Late-Life Depression

Vieira, T. S., Oude Voshaar, R., De Deyn, P., Dierckx, R. & van Waarde, A., 2014, PET and SPECT in Psychiatry. Dierckx, R. AJO., Otte, A., de Vries, E. FJ., van Waarde, A. & den Boer, J. A. (eds.). Heidelberg: Springer, p. 185-208 24 p. 7

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

Late-life late onset depression (i.e., depression with an age of onset above 60
yrs) appears to differ from depression with early onset in its association with
cerebral small vessel disease, beta-amyloid and tau deposition, and neurodegenerative processes. Multimodality imaging (SPECT, PET, MRI) supports this concept and the notion that late-life depression relies on dysfunctioning of the frontal lobe, but also highlights that mechanisms underlying late-onset depression are heterogeneous and diverse. The future of PET and SPECT imaging in depression research relies on progress in data analysis, the development of novel molecular probes for specifi c cerebral targets, and combination of different imaging modalities (e.g., PET and MRI). Relatively unexplored areas for future research are gender differences, longitudinal changes of brain function associated with subclinical and clinical depression, and analysis of the default network activity.
Original languageEnglish
Title of host publicationPET and SPECT in Psychiatry
EditorsRudi AJO Dierckx, Andreas Otte, Erik FJ de Vries, Aren van Waarde, Johan A den Boer
Place of PublicationHeidelberg
PublisherSpringer
Pages185-208
Number of pages24
ISBN (Electronic)978-3-642-40384-2
ISBN (Print)978-3-642-40383-5
Publication statusPublished - 2014

    Keywords

  • DEPRESSED OLDER ADULTS, Depression age of onset, POSITRON EMISSION TOMOGRAPHY, SEROTONERGIC SYSTEM, CEREBRAL BLOOD FLOW, cerebral glucose metabolism, REVIEW, CHOLINERGIC SYSTEM, BETA-AMYLOID, MILD COGNITIVE IMPAIRMENT

ID: 15955244