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Sodium Intake, ACE Inhibition, and Progression to ESRD

Vegter, S., Perna, A., Postma, M. J., Navis, G., Remuzzi, G. & Ruggenenti, P., Jan-2012, In : Journal of the American Society of Nephrology. 23, 1, p. 165-173 9 p.

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DOI

High sodium intake limits the antihypertensive and antiproteinuric effects of angiotensin-converting enzyme (ACE) inhibitors in patients with CKD; however, whether dietary sodium also associates with progression to ESRD is unknown. We conducted a post hoc analysis of the first and second Ramipril Efficacy in Nephropathy trials to evaluate the association of sodium intake with proteinuria and progression to ESRD among 500 CKD patients without diabetes who were treated with ramipril (5 mg/d) and monitored with serial 24-hour urinary sodium and creatinine measurements. Urinary sodium/creatinine excretion defined low (= 200 mEq/g) sodium intake. During a follow-up of >4.25 years, 92 individuals (18.4%) developed ESRD. Among those with low, medium, and high sodium intakes, the incidence of ESRD was 6.1 (95% confidence interval [95% Cl], 3.8-9.7), 7.9 (95% Cl, 6.1-10.2), and 18.2 (95% Cl, 11.3-29.3) per 100 patient-years, respectively (P14 g daily) seems to blunt the antiproteinuric effect of ACE inhibitor therapy and increase the risk for ESRD, independent of BP control.

Original languageEnglish
Pages (from-to)165-173
Number of pages9
JournalJournal of the American Society of Nephrology
Volume23
Issue number1
Publication statusPublished - Jan-2012

    Keywords

  • ANGIOTENSIN-CONVERTING ENZYME, RANDOMIZED CONTROLLED-TRIAL, GLOMERULAR-FILTRATION-RATE, CHRONIC KIDNEY-DISEASE, CHRONIC RENAL-DISEASE, DIETARY-SODIUM, BLOOD-PRESSURE, NONDIABETIC NEPHROPATHIES, ANTIPROTEINURIC EFFICACY, ESSENTIAL-HYPERTENSION

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