Publication

Social cognitive group treatment for impaired insight in psychosis: A multicenter randomized controlled trial

Pijnenborg, G. H. M., de Vos, A. E., Timmerman, M. E., Van der Gaag, M., Sportel, B. E., Arends, J., Koopmans, E. M., Van der Meer, L. & Aleman, A., Apr-2019, In : Schizophrenia Research. 206, p. 362-369 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Pijnenborg, G. H. M., de Vos, A. E., Timmerman, M. E., Van der Gaag, M., Sportel, B. E., Arends, J., ... Aleman, A. (2019). Social cognitive group treatment for impaired insight in psychosis: A multicenter randomized controlled trial. Schizophrenia Research, 206, 362-369. https://doi.org/10.1016/j.schres.2018.10.018

Author

Pijnenborg, G. H. M. ; de Vos, A. E. ; Timmerman, M. E. ; Van der Gaag, M. ; Sportel, B. E. ; Arends, J. ; Koopmans, E. M. ; Van der Meer, L. ; Aleman, A. / Social cognitive group treatment for impaired insight in psychosis : A multicenter randomized controlled trial. In: Schizophrenia Research. 2019 ; Vol. 206. pp. 362-369.

Harvard

Pijnenborg, GHM, de Vos, AE, Timmerman, ME, Van der Gaag, M, Sportel, BE, Arends, J, Koopmans, EM, Van der Meer, L & Aleman, A 2019, 'Social cognitive group treatment for impaired insight in psychosis: A multicenter randomized controlled trial', Schizophrenia Research, vol. 206, pp. 362-369. https://doi.org/10.1016/j.schres.2018.10.018

Standard

Social cognitive group treatment for impaired insight in psychosis : A multicenter randomized controlled trial. / Pijnenborg, G. H. M.; de Vos, A. E.; Timmerman, M. E.; Van der Gaag, M.; Sportel, B. E.; Arends, J.; Koopmans, E. M.; Van der Meer, L.; Aleman, A.

In: Schizophrenia Research, Vol. 206, 04.2019, p. 362-369.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Pijnenborg GHM, de Vos AE, Timmerman ME, Van der Gaag M, Sportel BE, Arends J et al. Social cognitive group treatment for impaired insight in psychosis: A multicenter randomized controlled trial. Schizophrenia Research. 2019 Apr;206:362-369. https://doi.org/10.1016/j.schres.2018.10.018


BibTeX

@article{082ac33f9ebb427ba61a2e8c8cb768db,
title = "Social cognitive group treatment for impaired insight in psychosis: A multicenter randomized controlled trial",
abstract = "Purpose: The majority of people with schizophrenia has impaired insight, which is related to a poorer outcome. In this study, we evaluate a new psychosocial intervention 'REFLEX' aimed at improving insight in people with schizophrenia. REFLEX focuses on targeting stigma-sensitivity, perspective taking and self-reflection in people with schizophrenia and low insight. Primary objective is to improve insight and subsequently to improve functional outcome and symptoms.Method: A total of 121 people diagnosed with schizophrenia according to DSM IV criteria with impaired insight was included in 2012-2015 from seven sites in a multicenter randomized controlled trial. REFLEX was compared to an active control condition consisting of group-wise simplified cognitive remediation training. Primary outcome of the study were the preconditions of insight: internalized stigma, self-reflection, mental flexibility and perspective taking. Clinical insight and cognitive insight were secondary outcomes.Results: Although perspective taking, self-reflection, mental flexibility and stigma sensitivity remained unchanged after the intervention, results showed a significant improvement of clinical insight in both conditions directly after treatment (SAI-E Rater, p <.001, PANSS G12, p <.005) and at follow-up (SAI-E Rater, p <.01, SAI-E interview, p <.001, PANSS G12, p <.0001). Improvement of clinical insight directly after treatment was larger in the REFLEX condition (SAI-E Rater, p <.05). Other outcomes (self-esteem, quality of life and depression) remained unchanged.Conclusion: Though insight improved in both conditions, REFLEX was not superior to simplified drill-and-practice cognitive remediation training. Nevertheless, this study indicates that structured interventions can significantly improve insight. Further research on the underlying mechanisms of both conditions is needed, as insight is unlikely to improve spontaneously in chronic patients. (C) 2018 Published by Elsevier B.V.",
keywords = "Awareness, Schizophrenia, Self-reflection, Perspective taking, Clinical trial, Self-stigma, REPORT QIDS-SR, INTERNALIZED STIGMA, SELF-STIGMA, QUICK INVENTORY, MENTAL-ILLNESS, POOR INSIGHT, SCHIZOPHRENIA, SCALE, INDIVIDUALS, IMPAIRMENTS",
author = "Pijnenborg, {G. H. M.} and {de Vos}, {A. E.} and Timmerman, {M. E.} and {Van der Gaag}, M. and Sportel, {B. E.} and J. Arends and Koopmans, {E. M.} and {Van der Meer}, L. and A. Aleman",
year = "2019",
month = "4",
doi = "10.1016/j.schres.2018.10.018",
language = "English",
volume = "206",
pages = "362--369",
journal = "Schizophrenia Research",
issn = "0920-9964",
publisher = "ELSEVIER SCIENCE BV",

}

RIS

TY - JOUR

T1 - Social cognitive group treatment for impaired insight in psychosis

T2 - A multicenter randomized controlled trial

AU - Pijnenborg, G. H. M.

AU - de Vos, A. E.

AU - Timmerman, M. E.

AU - Van der Gaag, M.

AU - Sportel, B. E.

AU - Arends, J.

AU - Koopmans, E. M.

AU - Van der Meer, L.

AU - Aleman, A.

PY - 2019/4

Y1 - 2019/4

N2 - Purpose: The majority of people with schizophrenia has impaired insight, which is related to a poorer outcome. In this study, we evaluate a new psychosocial intervention 'REFLEX' aimed at improving insight in people with schizophrenia. REFLEX focuses on targeting stigma-sensitivity, perspective taking and self-reflection in people with schizophrenia and low insight. Primary objective is to improve insight and subsequently to improve functional outcome and symptoms.Method: A total of 121 people diagnosed with schizophrenia according to DSM IV criteria with impaired insight was included in 2012-2015 from seven sites in a multicenter randomized controlled trial. REFLEX was compared to an active control condition consisting of group-wise simplified cognitive remediation training. Primary outcome of the study were the preconditions of insight: internalized stigma, self-reflection, mental flexibility and perspective taking. Clinical insight and cognitive insight were secondary outcomes.Results: Although perspective taking, self-reflection, mental flexibility and stigma sensitivity remained unchanged after the intervention, results showed a significant improvement of clinical insight in both conditions directly after treatment (SAI-E Rater, p <.001, PANSS G12, p <.005) and at follow-up (SAI-E Rater, p <.01, SAI-E interview, p <.001, PANSS G12, p <.0001). Improvement of clinical insight directly after treatment was larger in the REFLEX condition (SAI-E Rater, p <.05). Other outcomes (self-esteem, quality of life and depression) remained unchanged.Conclusion: Though insight improved in both conditions, REFLEX was not superior to simplified drill-and-practice cognitive remediation training. Nevertheless, this study indicates that structured interventions can significantly improve insight. Further research on the underlying mechanisms of both conditions is needed, as insight is unlikely to improve spontaneously in chronic patients. (C) 2018 Published by Elsevier B.V.

AB - Purpose: The majority of people with schizophrenia has impaired insight, which is related to a poorer outcome. In this study, we evaluate a new psychosocial intervention 'REFLEX' aimed at improving insight in people with schizophrenia. REFLEX focuses on targeting stigma-sensitivity, perspective taking and self-reflection in people with schizophrenia and low insight. Primary objective is to improve insight and subsequently to improve functional outcome and symptoms.Method: A total of 121 people diagnosed with schizophrenia according to DSM IV criteria with impaired insight was included in 2012-2015 from seven sites in a multicenter randomized controlled trial. REFLEX was compared to an active control condition consisting of group-wise simplified cognitive remediation training. Primary outcome of the study were the preconditions of insight: internalized stigma, self-reflection, mental flexibility and perspective taking. Clinical insight and cognitive insight were secondary outcomes.Results: Although perspective taking, self-reflection, mental flexibility and stigma sensitivity remained unchanged after the intervention, results showed a significant improvement of clinical insight in both conditions directly after treatment (SAI-E Rater, p <.001, PANSS G12, p <.005) and at follow-up (SAI-E Rater, p <.01, SAI-E interview, p <.001, PANSS G12, p <.0001). Improvement of clinical insight directly after treatment was larger in the REFLEX condition (SAI-E Rater, p <.05). Other outcomes (self-esteem, quality of life and depression) remained unchanged.Conclusion: Though insight improved in both conditions, REFLEX was not superior to simplified drill-and-practice cognitive remediation training. Nevertheless, this study indicates that structured interventions can significantly improve insight. Further research on the underlying mechanisms of both conditions is needed, as insight is unlikely to improve spontaneously in chronic patients. (C) 2018 Published by Elsevier B.V.

KW - Awareness

KW - Schizophrenia

KW - Self-reflection

KW - Perspective taking

KW - Clinical trial

KW - Self-stigma

KW - REPORT QIDS-SR

KW - INTERNALIZED STIGMA

KW - SELF-STIGMA

KW - QUICK INVENTORY

KW - MENTAL-ILLNESS

KW - POOR INSIGHT

KW - SCHIZOPHRENIA

KW - SCALE

KW - INDIVIDUALS

KW - IMPAIRMENTS

U2 - 10.1016/j.schres.2018.10.018

DO - 10.1016/j.schres.2018.10.018

M3 - Article

VL - 206

SP - 362

EP - 369

JO - Schizophrenia Research

JF - Schizophrenia Research

SN - 0920-9964

ER -

ID: 84095509