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SNP-Based Heritability Estimates of Common and Specific Variance in Self-and Informant-Reported Neuroticism Scales

Realo, A., van der Most, P. J., Allik, J., Esko, T., Jeronimus, B. F., Koots-Ausmees, L., Mottus, R., Tropf, F. C., Snieder, H. & Ormel, J., Dec-2017, In : Journal of Personality. 85, 6, p. 906-919 14 p.

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  • SNP-Based Heritability Estimates of Common and Specific Variance in Self- and Informant-Reported Neuroticism Scales

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DOI

Objective: Our study aims to estimate the proportion of the phenotypic variance of Neuroticism and its facet scales that can be attributed to common single-nucleotide polymorphisms (SNPs) in two adult populations from Estonia (EGCUT; N53,292) and the Netherlands (Lifelines; N513,383).

Method: Genomic-relatedness-matrix restricted maximum likelihood (GREML) using genome-wide complex trait analysis (GCTA) software was employed. To build upon previous research, we used self-and informant reports of the 30-facet NEO personality inventories and analyzed both the usual sum scores and the residual facet scores of Neuroticism.

Results: In the EGCUT cohort, the proportion of phenotypic variance explained by the additive effects of common genetic variants in self-and informant-reported Neuroticism domain scores was 15.2% (p=.070, SE=.11) and 6.2% (p=.293, SE=.12), respectively. The SNP-based heritability estimates at the level of Neuroticism facet scales differed greatly across cohorts and modes of measurement but were generally higher (a) for self-than for informant reports, and (b) for sum than for residual scores.

Conclusions: Our findings indicate that a large proportion of the heritability of Neuroticism is not captured by additive genetic effects of common SNPs, with some evidence for Gene 3 Environment interaction across cohorts.

Original languageEnglish
Pages (from-to)906-919
Number of pages14
JournalJournal of Personality
Volume85
Issue number6
Early online date13-Feb-2017
Publication statusPublished - Dec-2017

    Keywords

  • Neuroticism, GREML-GCTA, SNP-based heritability, self-versus informant reports, sum versus residual scores, GENOME-WIDE ASSOCIATION, MAJOR DEPRESSIVE DISORDER, CROSS-CULTURAL TWIN, NEO-PI-R, MISSING HERITABILITY, GENETIC-VARIATION, HUMAN PERSONALITY, ENVIRONMENTAL-INFLUENCES, PSYCHOBIOLOGICAL MODEL, POLYMORPHISM 5-HTTLPR
Related Datasets
  1. Lifelines Biobank

    Bakker, S. (Creator), Dotinga, A. (Creator), Vonk, J. (Creator), Smidt, N. (Creator), Scholtens, S. (Creator), Swertz, M. (Creator), Wijmenga, C. (Creator), Wolffenbuttel, B. (Creator), Stolk, R. (Creator), Zon, van, S. (Creator), Rosmalen, J. (Creator), Postma, D. S. (Creator), Boer, de, R. (Creator), Navis, G. (Creator), Slaets, J. (Creator), Ormel, J. (Creator), Dijk, van, F. (Creator), Lifelines, 2006

    Dataset

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ID: 37984669