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Sleep in seasonal affective disorder patients in forced desynchrony: an explorative study

Koorengevel, K. M., Beersma, D. G. M., den Boer, J. & Hoofdakker, R. H. V. D., Dec-2002, In : Journal of Sleep Research. 11, 4, p. 347-356 10 p.

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  • Kathelijne M. Koorengevel
  • Domien G.M. Beersma
  • Johan den Boer
  • Rutger H. van den Hoofdakker

The majority of winter-type seasonal affective disorder (SAD) patients complain of hypersomnia and daytime drowsiness. As human sleep is regulated by the interaction of circadian, ultradian and homeostatic processes, sleep disturbances may be caused by either one of these factors. The present study focuses on homeostatic and ultradian aspects of sleep regulation in SAD. Sleep was recorded polysomnographically in seven SAD patients and matched controls subjected to a 120-h forced desynchrony protocol. In time isolation, subjects were exposed to six 20-h days, each comprising a 6.5-h period for sleep. Patients participated while being depressed, while remitted after light therapy and in summer. Controls were studied in winter and in summer. In each condition, the data of each subject were averaged across all recordings. Thus, the influence of the effects of the circadian pacemaker on sleep was excluded mathematically. The comparison of patients with controls and with themselves in the various conditions revealed no abnormalities in homeostatic parameters: sleep stage variables, relative power spectra and time courses of power in various frequency bands across the first three non-rapid eye movement rapid eye movement ( NREM REM) cycles showed no differences. The data suggest that homeostatic processes are not involved in the disturbance of sleep in SAD.

Original languageEnglish
Pages (from-to)347-356
Number of pages10
JournalJournal of Sleep Research
Volume11
Issue number4
Publication statusPublished - Dec-2002

    Keywords

  • circadian pacemaker, forced desynchrony, process C, process S, seasonal affective disorder, sleep regulation, SLOW-WAVE ACTIVITY, CIRCADIAN PACEMAKER, PSYCHIATRIC-DISORDERS, LIGHT TREATMENT, HUMANS, EEG, ELECTROENCEPHALOGRAM, RHYTHMS, TEMPERATURE, DEPRIVATION

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