Publication

Skin autofluorescence assessment of cardiovascular risk in people with severe mental illness

Emmerink, D., Bakker, S., Van Bemmel, T., Noorthoorn, E. O. & Naarding, P., Jul-2018, In : BJPsych Open. 4, 4, p. 313-316 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

  • Danielle Emmerink
  • Sybiel Bakker
  • Thomas Van Bemmel
  • Eric O. Noorthoorn
  • Paul Naarding

Background

People with severe mental illness (SMI) show significantly shorter life expectancy, mostly due to more prevalent cardiovascular disease. Although age is a prominent contributor to contemporary risk assessment and SMI usually affects younger people, these assessments still do not reveal the actual risk. By assessing advanced glycation end products (AGEs), cardiovascular risk can be assessed independent of age.

Aims

To establish whether detection of AGEs with the AGE-reader will give a more accurate cardiovascular risk assessment in people with SMI.

Method

We compared assessment with the AGE-reader with that of the Systematic Coronary Risk Evaluation (SCORE) table in a group of 120 patients with SMI.

Results

The AGE-reader showed an increased cardiovascular risk more often than the SCORE table, especially in the youngest group.

Conclusions

Because of its ease of use and substantiation by studies done on other chronic diseases, we advocate use of the AGE-reader in daily care for patients with SMI to detect cardiovascular risk as early as possible. However, the findings of the current study should be evaluated with caution and should be seen as preliminary findings that require confirmation by a prospective longitudinal cohort study with a substantial follow-up observation period. (c) The Royal College of Psychiatrists 2018.

Original languageEnglish
Pages (from-to)313-316
Number of pages4
JournalBJPsych Open
Volume4
Issue number4
Publication statusPublished - Jul-2018

    Keywords

  • GLYCATION END-PRODUCTS, MYOCARDIAL-INFARCTION, MORTALITY, STRESS, SCORE

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