Single-cell sequencing to quantify genomic integrity in cancer

van den Bos, H., Bakker, B., Spierings, D. C. J., Lansdorp, P. M. & Foijer, F. 23-Sep-2017 In : International journal of biochemistry & cell biology.

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  • Single-cell sequencing to quantify genomic integrity in cancer

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The use of single-cell DNA sequencing (sc-seq) techniques for the diagnosis, prognosis and treatment of cancer is a rapidly developing field. Sc-seq research is gaining momentum by decreased sequencing costs and continuous improvements in techniques. In this review, we provide an overview of recent advancements in the field of sc-seq in cancer and we discuss how sc-seq can contribute to improved care for cancer patients. Sc-seq has made it possible to study the genomes of individual cancer cells from primary tumors, metastases and circulating tumor cells, revealing inter- and intra-tumor heterogeneity, which cannot be detected using other methods We review studies on individual human cancer cells in relation to prognosis and treatment response. Finally, future perspectives of sc-seq in cancer diagnosis and treatment are discussed with a focus on the use of circulating tumor cells to monitor therapy response and the development of personalized treatments based on knowledge about the genomic heterogeneity.

Original languageEnglish
JournalInternational journal of biochemistry & cell biology
StateE-pub ahead of print - 23-Sep-2017


  • Journal Article

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