Publication

Simvastatin affects cell motility and actin cytoskeleton distribution of microglia

Kuipers, HF., Rappert, A. A. C., Mommaas, AM., Van Haastert, ES., Van der Valk, P., Boddeke, HWGM., Biber, KPH. & Van den Elsen, PJ., 15-Jan-2006, In : Glia.. 53, 2, p. 115-123 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Kuipers, HF., Rappert, A. A. C., Mommaas, AM., Van Haastert, ES., Van der Valk, P., Boddeke, HWGM., Biber, KPH., & Van den Elsen, PJ. (2006). Simvastatin affects cell motility and actin cytoskeleton distribution of microglia. Glia., 53(2), 115-123. https://doi.org/10.1002/glia.20269

Author

Kuipers, HF ; Rappert, Angelika A.C. ; Mommaas, AM ; Van Haastert, ES ; Van der Valk, P ; Boddeke, HWGM ; Biber, KPH ; Van den Elsen, PJ. / Simvastatin affects cell motility and actin cytoskeleton distribution of microglia. In: Glia. 2006 ; Vol. 53, No. 2. pp. 115-123.

Harvard

Kuipers, HF, Rappert, AAC, Mommaas, AM, Van Haastert, ES, Van der Valk, P, Boddeke, HWGM, Biber, KPH & Van den Elsen, PJ 2006, 'Simvastatin affects cell motility and actin cytoskeleton distribution of microglia', Glia., vol. 53, no. 2, pp. 115-123. https://doi.org/10.1002/glia.20269

Standard

Simvastatin affects cell motility and actin cytoskeleton distribution of microglia. / Kuipers, HF; Rappert, Angelika A.C.; Mommaas, AM; Van Haastert, ES; Van der Valk, P; Boddeke, HWGM; Biber, KPH; Van den Elsen, PJ.

In: Glia., Vol. 53, No. 2, 15.01.2006, p. 115-123.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Kuipers HF, Rappert AAC, Mommaas AM, Van Haastert ES, Van der Valk P, Boddeke HWGM et al. Simvastatin affects cell motility and actin cytoskeleton distribution of microglia. Glia. 2006 Jan 15;53(2):115-123. https://doi.org/10.1002/glia.20269


BibTeX

@article{ab7258dbb65c4b3b89945d450ca701d7,
title = "Simvastatin affects cell motility and actin cytoskeleton distribution of microglia",
abstract = "Statin treatment is proposed to be a new potential therapy for multiple sclerosis (MS), an inflammatory demyelinating disease of the central nervous system. The effects of statin treatment on brain cells, however, are hardly understood. We therefore evaluated the effects of simvastatin treatment on the migratory capacity of brain microglial cells, key elements in the pathogenesis of MS. It is shown that exposure of human and murine microglial cells to simvastatin reduced cell surface expression of the chemokine receptors CCR5 and CXCR3. In addition, simvastatin treatment specifically abolished chemokine-induced microglial cell motility, altered actin cytoskeleton distribution, and led to changes in intracellular vesicles. These data clearly show that simvastatin inhibits several immunological properties of microglia, which may provide a rationale for statin treatment in MS. (c) 2005 Wiley-Liss, Inc.",
keywords = "statins, microglia, chemotaxis, multiple sclerosis, CENTRAL-NERVOUS-SYSTEM, EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS, MEMBRANE RAFT MICRODOMAINS, HMG-COA REDUCTASE, MULTIPLE-SCLEROSIS, IN-VITRO, BRAIN-TISSUE, EXPRESSION, LOVASTATIN, STATINS",
author = "HF Kuipers and Rappert, {Angelika A.C.} and AM Mommaas and {Van Haastert}, ES and {Van der Valk}, P and HWGM Boddeke and KPH Biber and {Van den Elsen}, PJ",
year = "2006",
month = jan,
day = "15",
doi = "10.1002/glia.20269",
language = "English",
volume = "53",
pages = "115--123",
journal = "Glia",
issn = "0894-1491",
publisher = "Wiley",
number = "2",

}

RIS

TY - JOUR

T1 - Simvastatin affects cell motility and actin cytoskeleton distribution of microglia

AU - Kuipers, HF

AU - Rappert, Angelika A.C.

AU - Mommaas, AM

AU - Van Haastert, ES

AU - Van der Valk, P

AU - Boddeke, HWGM

AU - Biber, KPH

AU - Van den Elsen, PJ

PY - 2006/1/15

Y1 - 2006/1/15

N2 - Statin treatment is proposed to be a new potential therapy for multiple sclerosis (MS), an inflammatory demyelinating disease of the central nervous system. The effects of statin treatment on brain cells, however, are hardly understood. We therefore evaluated the effects of simvastatin treatment on the migratory capacity of brain microglial cells, key elements in the pathogenesis of MS. It is shown that exposure of human and murine microglial cells to simvastatin reduced cell surface expression of the chemokine receptors CCR5 and CXCR3. In addition, simvastatin treatment specifically abolished chemokine-induced microglial cell motility, altered actin cytoskeleton distribution, and led to changes in intracellular vesicles. These data clearly show that simvastatin inhibits several immunological properties of microglia, which may provide a rationale for statin treatment in MS. (c) 2005 Wiley-Liss, Inc.

AB - Statin treatment is proposed to be a new potential therapy for multiple sclerosis (MS), an inflammatory demyelinating disease of the central nervous system. The effects of statin treatment on brain cells, however, are hardly understood. We therefore evaluated the effects of simvastatin treatment on the migratory capacity of brain microglial cells, key elements in the pathogenesis of MS. It is shown that exposure of human and murine microglial cells to simvastatin reduced cell surface expression of the chemokine receptors CCR5 and CXCR3. In addition, simvastatin treatment specifically abolished chemokine-induced microglial cell motility, altered actin cytoskeleton distribution, and led to changes in intracellular vesicles. These data clearly show that simvastatin inhibits several immunological properties of microglia, which may provide a rationale for statin treatment in MS. (c) 2005 Wiley-Liss, Inc.

KW - statins

KW - microglia

KW - chemotaxis

KW - multiple sclerosis

KW - CENTRAL-NERVOUS-SYSTEM

KW - EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS

KW - MEMBRANE RAFT MICRODOMAINS

KW - HMG-COA REDUCTASE

KW - MULTIPLE-SCLEROSIS

KW - IN-VITRO

KW - BRAIN-TISSUE

KW - EXPRESSION

KW - LOVASTATIN

KW - STATINS

U2 - 10.1002/glia.20269

DO - 10.1002/glia.20269

M3 - Article

VL - 53

SP - 115

EP - 123

JO - Glia

JF - Glia

SN - 0894-1491

IS - 2

ER -

ID: 1528648