Publication

Simvastatin affects cell motility and actin cytoskeleton distribution of microglia

Kuipers, HF., Rappert, A. A. C., Mommaas, AM., Van Haastert, ES., Van der Valk, P., Boddeke, HWGM., Biber, KPH. & Van den Elsen, PJ., 15-Jan-2006, In : Glia.. 53, 2, p. 115-123 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

  • HF Kuipers
  • Angelika A.C. Rappert
  • AM Mommaas
  • ES Van Haastert
  • P Van der Valk
  • HWGM Boddeke
  • KPH Biber
  • PJ Van den Elsen

Statin treatment is proposed to be a new potential therapy for multiple sclerosis (MS), an inflammatory demyelinating disease of the central nervous system. The effects of statin treatment on brain cells, however, are hardly understood. We therefore evaluated the effects of simvastatin treatment on the migratory capacity of brain microglial cells, key elements in the pathogenesis of MS. It is shown that exposure of human and murine microglial cells to simvastatin reduced cell surface expression of the chemokine receptors CCR5 and CXCR3. In addition, simvastatin treatment specifically abolished chemokine-induced microglial cell motility, altered actin cytoskeleton distribution, and led to changes in intracellular vesicles. These data clearly show that simvastatin inhibits several immunological properties of microglia, which may provide a rationale for statin treatment in MS. (c) 2005 Wiley-Liss, Inc.

Original languageEnglish
Pages (from-to)115-123
Number of pages9
JournalGlia.
Volume53
Issue number2
Publication statusPublished - 15-Jan-2006

    Keywords

  • statins, microglia, chemotaxis, multiple sclerosis, CENTRAL-NERVOUS-SYSTEM, EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS, MEMBRANE RAFT MICRODOMAINS, HMG-COA REDUCTASE, MULTIPLE-SCLEROSIS, IN-VITRO, BRAIN-TISSUE, EXPRESSION, LOVASTATIN, STATINS

ID: 1528648