Publication

Simultaneous assessment of microvascular oxygen saturation and laser-doppler flow in gastric mucosa

Fournell, A., Scheeren, TWL. & Schwarte, LA., 2003, OXYGEN TRANSPORT TO TISSUE XXV. Thorniley, M., Harrison, DK. & James, PE. (eds.). Kluwer Academic/Plenum Publishers, p. 47-53 7 p. (ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY; vol. 540).

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

Positive end-expiratory pressure (PEEP) during controlled mechanical ventilation has been shown to reduce the oxygen saturation of hemoglobin in gastric mucosa (μHbO2)1 and splanchnic microvascular blood flow.2 The effects of PEEP on these microcirculatory variables could be separated from the impact of PEEP on systemic circulation and oxygenation: Normalization of cardiac output and oxygen transport capacity, depressed due to reduced preload during ventilation with PEEP, did not restore microvascular blood flow2 nor 1.μHbO2.3 Similarly, in healthy volunteers breathing continuous positive airway pressure (CPAP) reduced tHbO2 despite unchanged systemic hemodynamics and stable systemic oxygen saturation.4 The mechanism for this obvious different response to PEEP and CPAP in systemic and regional intestinal circulation remains unclear.
Original languageEnglish
Title of host publicationOXYGEN TRANSPORT TO TISSUE XXV
EditorsM Thorniley, DK Harrison, PE James
PublisherKluwer Academic/Plenum Publishers
Pages47-53
Number of pages7
ISBN (Print)0-306-48035-2
Publication statusPublished - 2003
Externally publishedYes
Event30th Scientific Meeting of the International-Society-on-Oxygen-Transport-to-Tissue (ISOTT) - MANCHESTER, Netherlands
Duration: 1-Aug-2002 → …

Publication series

NameADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY
PublisherKLUWER ACADEMIC/PLENUM PUBL
Volume540
ISSN (Print)0065-2598

Conference

Conference30th Scientific Meeting of the International-Society-on-Oxygen-Transport-to-Tissue (ISOTT)
CountryNetherlands
Period01/08/2002 → …

Event

30th Scientific Meeting of the International-Society-on-Oxygen-Transport-to-Tissue (ISOTT)

01/08/2002 → …

Netherlands

Event: Conference

    Keywords

  • CARDIAC-OUTPUT, BLOOD-FLOW, NORMALIZATION

ID: 22390937