Publication

Similar association between objective and subjective symptoms in functional and organic tremor

Kramer, G., Dominguez-Vega, Z. T., Laarhoven, H. S. A., Brandsma, R., Smit, M., van der Stouwe, A. M. M., Elting, J. W. J., Maurits, N. M., Rosmalen, J. G. M. & Tijssen, M. A. J., Jul-2019, In : Parkinsonism & Related Disorders. 64, p. 2-7 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Kramer, G., Dominguez-Vega, Z. T., Laarhoven, H. S. A., Brandsma, R., Smit, M., van der Stouwe, A. M. M., ... Tijssen, M. A. J. (2019). Similar association between objective and subjective symptoms in functional and organic tremor. Parkinsonism & Related Disorders, 64, 2-7. https://doi.org/10.1016/j.parkreldis.2019.05.026

Author

Kramer, Gerrit ; Dominguez-Vega, Zeus T. ; Laarhoven, Heleen S. A. ; Brandsma, Rick ; Smit, Marenka ; van der Stouwe, A. M. Madelein ; Elting, Jan Willem J. ; Maurits, Natasha M. ; Rosmalen, Judith G. M. ; Tijssen, Marina A. J. / Similar association between objective and subjective symptoms in functional and organic tremor. In: Parkinsonism & Related Disorders. 2019 ; Vol. 64. pp. 2-7.

Harvard

Kramer, G, Dominguez-Vega, ZT, Laarhoven, HSA, Brandsma, R, Smit, M, van der Stouwe, AMM, Elting, JWJ, Maurits, NM, Rosmalen, JGM & Tijssen, MAJ 2019, 'Similar association between objective and subjective symptoms in functional and organic tremor', Parkinsonism & Related Disorders, vol. 64, pp. 2-7. https://doi.org/10.1016/j.parkreldis.2019.05.026

Standard

Similar association between objective and subjective symptoms in functional and organic tremor. / Kramer, Gerrit; Dominguez-Vega, Zeus T.; Laarhoven, Heleen S. A.; Brandsma, Rick; Smit, Marenka; van der Stouwe, A. M. Madelein; Elting, Jan Willem J.; Maurits, Natasha M.; Rosmalen, Judith G. M.; Tijssen, Marina A. J.

In: Parkinsonism & Related Disorders, Vol. 64, 07.2019, p. 2-7.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Kramer G, Dominguez-Vega ZT, Laarhoven HSA, Brandsma R, Smit M, van der Stouwe AMM et al. Similar association between objective and subjective symptoms in functional and organic tremor. Parkinsonism & Related Disorders. 2019 Jul;64:2-7. https://doi.org/10.1016/j.parkreldis.2019.05.026


BibTeX

@article{c4502228fa714c038d09552260faecb2,
title = "Similar association between objective and subjective symptoms in functional and organic tremor",
abstract = "Background: A previous study reported a dramatic mismatch in objectively detected and self-reported tremor duration in patients with functional tremor. As these findings have an important and widespread impact in both clinical care and research, we conducted a validation study with a longer study duration and a larger sample of patients.Methods: Fourteen patients with functional tremor and 19 with organic tremor completed a 30 day study period. Objective tremor duration was recorded using a wrist-worn accelerometer. Simultaneously, participants completed a web-based diary five times a day, each time rating their symptom burden since the previous diary entry.Results: Patients with functional tremor had shorter objective tremor duration compared to patients with organic tremor (21.6{\%} vs 30.7{\%}, P = 0.034). A post-hoc analysis revealed the difference in objective duration was mainly due to patients with essential tremor (37.2{\%}). Subjective symptom burden was not significantly different between functional and organic tremors (38.7 vs 28.7 on a 0-100 VAS scale, P = 0.138). Finally, a mixed model analysis did not reveal significant differences in the association between subjective and objective tremor symptoms (P = 0.168).Conclusions: patients with functional tremor do have an objectively detectable, persistent tremor during daily life activities. Furthermore, they have a similar symptom burden and a similar association between subjective and objective tremor symptoms as patients with organic tremor.",
keywords = "Functional movement disorder, Tremor, Actigraphy, Self-report, Ambulatory assessment, PSYCHOGENIC MOVEMENT-DISORDERS, RATING-SCALE, PARKINSONS, TIME",
author = "Gerrit Kramer and Dominguez-Vega, {Zeus T.} and Laarhoven, {Heleen S. A.} and Rick Brandsma and Marenka Smit and {van der Stouwe}, {A. M. Madelein} and Elting, {Jan Willem J.} and Maurits, {Natasha M.} and Rosmalen, {Judith G. M.} and Tijssen, {Marina A. J.}",
year = "2019",
month = "7",
doi = "10.1016/j.parkreldis.2019.05.026",
language = "English",
volume = "64",
pages = "2--7",
journal = "Parkinsonism & Related Disorders",
issn = "1353-8020",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Similar association between objective and subjective symptoms in functional and organic tremor

AU - Kramer, Gerrit

AU - Dominguez-Vega, Zeus T.

AU - Laarhoven, Heleen S. A.

AU - Brandsma, Rick

AU - Smit, Marenka

AU - van der Stouwe, A. M. Madelein

AU - Elting, Jan Willem J.

AU - Maurits, Natasha M.

AU - Rosmalen, Judith G. M.

AU - Tijssen, Marina A. J.

PY - 2019/7

Y1 - 2019/7

N2 - Background: A previous study reported a dramatic mismatch in objectively detected and self-reported tremor duration in patients with functional tremor. As these findings have an important and widespread impact in both clinical care and research, we conducted a validation study with a longer study duration and a larger sample of patients.Methods: Fourteen patients with functional tremor and 19 with organic tremor completed a 30 day study period. Objective tremor duration was recorded using a wrist-worn accelerometer. Simultaneously, participants completed a web-based diary five times a day, each time rating their symptom burden since the previous diary entry.Results: Patients with functional tremor had shorter objective tremor duration compared to patients with organic tremor (21.6% vs 30.7%, P = 0.034). A post-hoc analysis revealed the difference in objective duration was mainly due to patients with essential tremor (37.2%). Subjective symptom burden was not significantly different between functional and organic tremors (38.7 vs 28.7 on a 0-100 VAS scale, P = 0.138). Finally, a mixed model analysis did not reveal significant differences in the association between subjective and objective tremor symptoms (P = 0.168).Conclusions: patients with functional tremor do have an objectively detectable, persistent tremor during daily life activities. Furthermore, they have a similar symptom burden and a similar association between subjective and objective tremor symptoms as patients with organic tremor.

AB - Background: A previous study reported a dramatic mismatch in objectively detected and self-reported tremor duration in patients with functional tremor. As these findings have an important and widespread impact in both clinical care and research, we conducted a validation study with a longer study duration and a larger sample of patients.Methods: Fourteen patients with functional tremor and 19 with organic tremor completed a 30 day study period. Objective tremor duration was recorded using a wrist-worn accelerometer. Simultaneously, participants completed a web-based diary five times a day, each time rating their symptom burden since the previous diary entry.Results: Patients with functional tremor had shorter objective tremor duration compared to patients with organic tremor (21.6% vs 30.7%, P = 0.034). A post-hoc analysis revealed the difference in objective duration was mainly due to patients with essential tremor (37.2%). Subjective symptom burden was not significantly different between functional and organic tremors (38.7 vs 28.7 on a 0-100 VAS scale, P = 0.138). Finally, a mixed model analysis did not reveal significant differences in the association between subjective and objective tremor symptoms (P = 0.168).Conclusions: patients with functional tremor do have an objectively detectable, persistent tremor during daily life activities. Furthermore, they have a similar symptom burden and a similar association between subjective and objective tremor symptoms as patients with organic tremor.

KW - Functional movement disorder

KW - Tremor

KW - Actigraphy

KW - Self-report

KW - Ambulatory assessment

KW - PSYCHOGENIC MOVEMENT-DISORDERS

KW - RATING-SCALE

KW - PARKINSONS

KW - TIME

U2 - 10.1016/j.parkreldis.2019.05.026

DO - 10.1016/j.parkreldis.2019.05.026

M3 - Article

VL - 64

SP - 2

EP - 7

JO - Parkinsonism & Related Disorders

JF - Parkinsonism & Related Disorders

SN - 1353-8020

ER -

ID: 99108583