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Similar association between objective and subjective symptoms in functional and organic tremor

Kramer, G., Dominguez-Vega, Z. T., Laarhoven, H. S. A., Brandsma, R., Smit, M., van der Stouwe, A. M. M., Elting, J. W. J., Maurits, N. M., Rosmalen, J. G. M. & Tijssen, M. A. J., Jul-2019, In : Parkinsonism & Related Disorders. 64, p. 2-7 6 p.

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  • Similar association between objective and subjective symptoms in functional and organic tremor

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Background: A previous study reported a dramatic mismatch in objectively detected and self-reported tremor duration in patients with functional tremor. As these findings have an important and widespread impact in both clinical care and research, we conducted a validation study with a longer study duration and a larger sample of patients.

Methods: Fourteen patients with functional tremor and 19 with organic tremor completed a 30 day study period. Objective tremor duration was recorded using a wrist-worn accelerometer. Simultaneously, participants completed a web-based diary five times a day, each time rating their symptom burden since the previous diary entry.

Results: Patients with functional tremor had shorter objective tremor duration compared to patients with organic tremor (21.6% vs 30.7%, P = 0.034). A post-hoc analysis revealed the difference in objective duration was mainly due to patients with essential tremor (37.2%). Subjective symptom burden was not significantly different between functional and organic tremors (38.7 vs 28.7 on a 0-100 VAS scale, P = 0.138). Finally, a mixed model analysis did not reveal significant differences in the association between subjective and objective tremor symptoms (P = 0.168).

Conclusions: patients with functional tremor do have an objectively detectable, persistent tremor during daily life activities. Furthermore, they have a similar symptom burden and a similar association between subjective and objective tremor symptoms as patients with organic tremor.

Original languageEnglish
Pages (from-to)2-7
Number of pages6
JournalParkinsonism & Related Disorders
Volume64
Publication statusPublished - Jul-2019

    Keywords

  • Functional movement disorder, Tremor, Actigraphy, Self-report, Ambulatory assessment, PSYCHOGENIC MOVEMENT-DISORDERS, RATING-SCALE, PARKINSONS, TIME

ID: 99108583