Publication

Signature of circulating microRNAs in patients with acute heart failure

Ovchinnikova, E. S., Schmitter, D., Vegter, E. L., ter Maaten, J. M., Valente, M. A. E., Liu, L. C. Y., van der Harst, P., Pinto, Y. M., de Boer, R. A., Meyer, S., Teerlink, J. R., O'Connor, C. M., Metra, M., Davison, B. A., Bloomfield, D. M., Cotter, G., Cleland, J. G., Mebazaa, A., Laribi, S., Givertz, M. M., Ponikowski, P., van der Meer, P., van Veldhuisen, D. J., Voors, A. A. & Berezikov, E., Apr-2016, In : European Journal of Heart Failure. 18, 4, p. 414-423 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Ovchinnikova, E. S., Schmitter, D., Vegter, E. L., ter Maaten, J. M., Valente, M. A. E., Liu, L. C. Y., ... Berezikov, E. (2016). Signature of circulating microRNAs in patients with acute heart failure. European Journal of Heart Failure, 18(4), 414-423. https://doi.org/10.1002/ejhf.332

Author

Ovchinnikova, Ekaterina S. ; Schmitter, Daniela ; Vegter, Eline L. ; ter Maaten, Jozine M. ; Valente, Mattia A. E. ; Liu, Licette C. Y. ; van der Harst, Pim ; Pinto, Yigal M. ; de Boer, Rudolf A. ; Meyer, Sven ; Teerlink, John R. ; O'Connor, Christopher M. ; Metra, Marco ; Davison, Beth A. ; Bloomfield, Daniel M. ; Cotter, Gadi ; Cleland, John G. ; Mebazaa, Alexandre ; Laribi, Said ; Givertz, Michael M. ; Ponikowski, Piotr ; van der Meer, Peter ; van Veldhuisen, Dirk J. ; Voors, Adriaan A. ; Berezikov, Eugene. / Signature of circulating microRNAs in patients with acute heart failure. In: European Journal of Heart Failure. 2016 ; Vol. 18, No. 4. pp. 414-423.

Harvard

Ovchinnikova, ES, Schmitter, D, Vegter, EL, ter Maaten, JM, Valente, MAE, Liu, LCY, van der Harst, P, Pinto, YM, de Boer, RA, Meyer, S, Teerlink, JR, O'Connor, CM, Metra, M, Davison, BA, Bloomfield, DM, Cotter, G, Cleland, JG, Mebazaa, A, Laribi, S, Givertz, MM, Ponikowski, P, van der Meer, P, van Veldhuisen, DJ, Voors, AA & Berezikov, E 2016, 'Signature of circulating microRNAs in patients with acute heart failure', European Journal of Heart Failure, vol. 18, no. 4, pp. 414-423. https://doi.org/10.1002/ejhf.332

Standard

Signature of circulating microRNAs in patients with acute heart failure. / Ovchinnikova, Ekaterina S.; Schmitter, Daniela; Vegter, Eline L.; ter Maaten, Jozine M.; Valente, Mattia A. E.; Liu, Licette C. Y.; van der Harst, Pim; Pinto, Yigal M.; de Boer, Rudolf A.; Meyer, Sven; Teerlink, John R.; O'Connor, Christopher M.; Metra, Marco; Davison, Beth A.; Bloomfield, Daniel M.; Cotter, Gadi; Cleland, John G.; Mebazaa, Alexandre; Laribi, Said; Givertz, Michael M.; Ponikowski, Piotr; van der Meer, Peter; van Veldhuisen, Dirk J.; Voors, Adriaan A.; Berezikov, Eugene.

In: European Journal of Heart Failure, Vol. 18, No. 4, 04.2016, p. 414-423.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Ovchinnikova ES, Schmitter D, Vegter EL, ter Maaten JM, Valente MAE, Liu LCY et al. Signature of circulating microRNAs in patients with acute heart failure. European Journal of Heart Failure. 2016 Apr;18(4):414-423. https://doi.org/10.1002/ejhf.332


BibTeX

@article{b64bb1d8f1ea490caa80d9154d7b6353,
title = "Signature of circulating microRNAs in patients with acute heart failure",
abstract = "AimsOur aim was to identify circulating microRNAs (miRNAs) associated with acute heart failure (AHF).Methods and resultsPlasma miRNA profiling included 137 patients with AHF from 3 different cohorts, 20 with chronic heart failure (CHF), 8 with acute exacerbation of COPD, and 41 healthy controls. Levels of circulating miRNAs were measured using quantitative reverse transcription-polymerase chain reaction (qRT-PCR). Plasma levels of miRNAs in patients with AHF were decreased compared with CHF patients or healthy subjects, whereas no significant changes were observed between acute COPD patients and controls. Fifteen miRNAs found in the discovery phase to differ most significantly between healthy controls and patients with AHF were further investigated in an extended cohort of 100 AHF patients at admission and a separate cohort of 18 AHF patients at different time points. Out of these 15 miRNAs, 12 could be confirmed in an additional AHF validation cohort and 7 passed the Bonferroni correction threshold (miR-18a-5p, miR-26b-5p, miR-27a-3p, miR-30e-5p, miR-106a-5p, miR-199a-3p, and miR-652-3p, all P <0.00005). A further drop in miRNA levels within 48 h after AHF admission was associated with an increased risk of 180-day mortality in a subset of the identified miRNAs.ConclusionsDeclining levels of circulating miRNAs were associated with increasing acuity of heart failure. Early in-hospital decreasing miRNA levels were predictive for mortality in a subset of miRNAs in patients with AHF. The discovered miRNA panel may serve as a launch-pad for molecular pathway studies to identify new pharmacological targets and miRNA-based therapies.",
keywords = "Heart failure, Circulating microRNAs, Biomarkers, DILATED CARDIOMYOPATHY, EJECTION FRACTION, CANDIDATE MARKERS, HYPERTROPHY, EXPRESSION, MIRNAS, BIOMARKERS, CARDIOMYOCYTES, MECHANISM, DIAGNOSIS",
author = "Ovchinnikova, {Ekaterina S.} and Daniela Schmitter and Vegter, {Eline L.} and {ter Maaten}, {Jozine M.} and Valente, {Mattia A. E.} and Liu, {Licette C. Y.} and {van der Harst}, Pim and Pinto, {Yigal M.} and {de Boer}, {Rudolf A.} and Sven Meyer and Teerlink, {John R.} and O'Connor, {Christopher M.} and Marco Metra and Davison, {Beth A.} and Bloomfield, {Daniel M.} and Gadi Cotter and Cleland, {John G.} and Alexandre Mebazaa and Said Laribi and Givertz, {Michael M.} and Piotr Ponikowski and {van der Meer}, Peter and {van Veldhuisen}, {Dirk J.} and Voors, {Adriaan A.} and Eugene Berezikov",
year = "2016",
month = "4",
doi = "10.1002/ejhf.332",
language = "English",
volume = "18",
pages = "414--423",
journal = "European Journal of Heart Failure",
issn = "1388-9842",
publisher = "Wiley",
number = "4",

}

RIS

TY - JOUR

T1 - Signature of circulating microRNAs in patients with acute heart failure

AU - Ovchinnikova, Ekaterina S.

AU - Schmitter, Daniela

AU - Vegter, Eline L.

AU - ter Maaten, Jozine M.

AU - Valente, Mattia A. E.

AU - Liu, Licette C. Y.

AU - van der Harst, Pim

AU - Pinto, Yigal M.

AU - de Boer, Rudolf A.

AU - Meyer, Sven

AU - Teerlink, John R.

AU - O'Connor, Christopher M.

AU - Metra, Marco

AU - Davison, Beth A.

AU - Bloomfield, Daniel M.

AU - Cotter, Gadi

AU - Cleland, John G.

AU - Mebazaa, Alexandre

AU - Laribi, Said

AU - Givertz, Michael M.

AU - Ponikowski, Piotr

AU - van der Meer, Peter

AU - van Veldhuisen, Dirk J.

AU - Voors, Adriaan A.

AU - Berezikov, Eugene

PY - 2016/4

Y1 - 2016/4

N2 - AimsOur aim was to identify circulating microRNAs (miRNAs) associated with acute heart failure (AHF).Methods and resultsPlasma miRNA profiling included 137 patients with AHF from 3 different cohorts, 20 with chronic heart failure (CHF), 8 with acute exacerbation of COPD, and 41 healthy controls. Levels of circulating miRNAs were measured using quantitative reverse transcription-polymerase chain reaction (qRT-PCR). Plasma levels of miRNAs in patients with AHF were decreased compared with CHF patients or healthy subjects, whereas no significant changes were observed between acute COPD patients and controls. Fifteen miRNAs found in the discovery phase to differ most significantly between healthy controls and patients with AHF were further investigated in an extended cohort of 100 AHF patients at admission and a separate cohort of 18 AHF patients at different time points. Out of these 15 miRNAs, 12 could be confirmed in an additional AHF validation cohort and 7 passed the Bonferroni correction threshold (miR-18a-5p, miR-26b-5p, miR-27a-3p, miR-30e-5p, miR-106a-5p, miR-199a-3p, and miR-652-3p, all P <0.00005). A further drop in miRNA levels within 48 h after AHF admission was associated with an increased risk of 180-day mortality in a subset of the identified miRNAs.ConclusionsDeclining levels of circulating miRNAs were associated with increasing acuity of heart failure. Early in-hospital decreasing miRNA levels were predictive for mortality in a subset of miRNAs in patients with AHF. The discovered miRNA panel may serve as a launch-pad for molecular pathway studies to identify new pharmacological targets and miRNA-based therapies.

AB - AimsOur aim was to identify circulating microRNAs (miRNAs) associated with acute heart failure (AHF).Methods and resultsPlasma miRNA profiling included 137 patients with AHF from 3 different cohorts, 20 with chronic heart failure (CHF), 8 with acute exacerbation of COPD, and 41 healthy controls. Levels of circulating miRNAs were measured using quantitative reverse transcription-polymerase chain reaction (qRT-PCR). Plasma levels of miRNAs in patients with AHF were decreased compared with CHF patients or healthy subjects, whereas no significant changes were observed between acute COPD patients and controls. Fifteen miRNAs found in the discovery phase to differ most significantly between healthy controls and patients with AHF were further investigated in an extended cohort of 100 AHF patients at admission and a separate cohort of 18 AHF patients at different time points. Out of these 15 miRNAs, 12 could be confirmed in an additional AHF validation cohort and 7 passed the Bonferroni correction threshold (miR-18a-5p, miR-26b-5p, miR-27a-3p, miR-30e-5p, miR-106a-5p, miR-199a-3p, and miR-652-3p, all P <0.00005). A further drop in miRNA levels within 48 h after AHF admission was associated with an increased risk of 180-day mortality in a subset of the identified miRNAs.ConclusionsDeclining levels of circulating miRNAs were associated with increasing acuity of heart failure. Early in-hospital decreasing miRNA levels were predictive for mortality in a subset of miRNAs in patients with AHF. The discovered miRNA panel may serve as a launch-pad for molecular pathway studies to identify new pharmacological targets and miRNA-based therapies.

KW - Heart failure

KW - Circulating microRNAs

KW - Biomarkers

KW - DILATED CARDIOMYOPATHY

KW - EJECTION FRACTION

KW - CANDIDATE MARKERS

KW - HYPERTROPHY

KW - EXPRESSION

KW - MIRNAS

KW - BIOMARKERS

KW - CARDIOMYOCYTES

KW - MECHANISM

KW - DIAGNOSIS

U2 - 10.1002/ejhf.332

DO - 10.1002/ejhf.332

M3 - Article

VL - 18

SP - 414

EP - 423

JO - European Journal of Heart Failure

JF - European Journal of Heart Failure

SN - 1388-9842

IS - 4

ER -

ID: 41100754