Publication

Shutting down the power supply for DNA repair in cancer cells

van Vugt, M. A. T. M., Feb-2017, In : The Journal of Cell Biology. 216, 2, p. 295-297 3 p.

Research output: Contribution to journalEditorialAcademicpeer-review

Phosphoglycerate mutase 1 (PGAM1) functions in glycolysis. In this issue, Qu et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201607008) show that PGAM1 inactivation leads to nucleotide depletion, which causes defective homologous recombination-mediated DNA repair, suggesting that targeting metabolic enzymes increases cancer cell susceptibility to DNA damaging agents.

Original languageEnglish
Pages (from-to)295-297
Number of pages3
JournalThe Journal of Cell Biology
Volume216
Issue number2
Publication statusPublished - Feb-2017

    Keywords

  • PHOSPHOGLYCERATE MUTASE, STRESS, DAMAGE, G2

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