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Short-term surgical outcome and safety of risk reducing salpingo-oophorectomy in BRCA1/2 mutation carriers

Kenkhuis, M. J. A., de Bock, G. H., Elferink, P. O., Arts, H. J. G., Oosterwijk, J. C., Jansen, L. & Mourits, M. J. E., Jul-2010, In : Maturitas. 66, 3, p. 310-314 5 p.

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  • Short-term surgical outcome and safety of risk reducing salpingo-oophorectomyinBRCA1/2mutation carriers

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Objective: Women with a BRCA1/2 mutation or members of a hereditary breast ovarian cancer family (HBOC) have an increased risk of developing ovarian cancer. The only effective strategy to reduce this risk is a risk reducing salpingo-oophorectomy (RRSO). The aim of this study was to evaluate the short-term surgical outcome and safety of a RRSO.

Patient and methods: Included were all consecutive women with a BRCA1/2 mutation or members of a HBOC family who visited our Family Cancer Clinic between September 1995 and March 2006, and choose for RRSO.

Results: 159 women were included, of which 97(61.0%) BRCA1 and 32(20.1%) BRCA2 mutation carriers, and 30 women of a HBOC family (18.9%). The median age at RRSO was 42.9 years (30.3-61.1) in the BRCA1 group, 48.4 years (33.5-66.9) in the BRCA2 group and 46.4(32.8-68.7) years in the HBOC group (p = 0.02). The median body mass index (BMI) was 24.9 kg/m(2), 30.1% were overweighed (BMI 25-30) and 18.7% were obese (BMI > 30). The RRSO was performed by primary laparoscopy (n = 154) or laparotomy (n = 5). Intraoperatively, one (0.6%) major complication occurred and laparoscopy was converted to laparotomy. In one patient (0.6%) a minor complication occurred. Post-operatively five minor complications (3.1%) were observed. Median hospital stay was 1 day (0-13 days).

Conclusion: Laparoscopic RRSO in BRCA1/2 mutation carriers seems to be a safe procedure with a low intraoperative and post-operative complication rate (1.3% and 3.1% respectively), a low conversion rate (0.6%) and a short median hospital stay (1.0 day). (C) 2010 Elsevier Ireland Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)310-314
Number of pages5
JournalMaturitas
Volume66
Issue number3
Publication statusPublished - Jul-2010

    Keywords

  • Adult, Aged, Breast Neoplasms/genetics, Fallopian Tubes/surgery, Female, Genes, BRCA1, Genes, BRCA2, Genetic Predisposition to Disease, Humans, Length of Stay, Middle Aged, Mutation, Obesity/epidemiology, Ovarian Neoplasms/genetics, Ovariectomy/adverse effects, Postoperative Complications, Treatment Outcome

ID: 5123796