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Short-Term Consumption of Sucralose with, but Not without, Carbohydrate Impairs Neural and Metabolic Sensitivity to Sugar in Humans

Dalenberg, J. R., Patel, B. P., Denis, R., Veldhuizen, M. G., Nakamura, Y., Vinke, P. C., Luquet, S. & Small, D. M., 3-Mar-2020, In : Cell metabolism. 31, 3, p. 493-502.e7 17 p.

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  • Short-Term Consumption of Sucralose with, but Not without, Carbohydrate Impairs Neural and Metabolic Sensitivity to Sugar in Humans

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DOI

There is a general consensus that overconsumption of sugar-sweetened beverages contributes to the prevalence of obesity and related comorbidities such as type 2 diabetes (T2D). Whether a similar relationship exists for no- or low-calorie "diet'' drinks is a subject of intensive debate and controversy. Here, we demonstrate that consuming seven sucralose-sweetened beverages with, but not without, a carbohydrate over 10 days decreases insulin sensitivity in healthy human participants, an effect that correlates with reductions in midbrain, insular, and cingulate responses to sweet, but not sour, salty, or savory, taste as assessed with fMRI. Taste perception was unaltered and consuming the carbohydrate alone had no effect. These findings indicate that consumption of sucralose in the presence of a carbohydrate rapidly impairs glucose metabolism and results in longer-term decreases in brain, but not perceptual sensitivity to sweet taste, suggesting dysregulation of gut-brain control of glucose metabolism.

Original languageEnglish
Pages (from-to)493-502.e7
Number of pages17
JournalCell metabolism
Volume31
Issue number3
Publication statusPublished - 3-Mar-2020

    Keywords

  • HIGH-INTENSITY SWEETENERS, LOW-CALORIE SWEETENERS, WEIGHT-GAIN, GLUCOSE-HOMEOSTASIS, INSULIN-RESISTANCE, BODY-WEIGHT, NONNUTRITIVE SWEETENERS, ARTIFICIAL SWEETENER, HORMONAL RESPONSES, TASTE RECEPTOR

ID: 134372723