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Sex-specific associations between Neutrophil Gelatinase-Associated Lipocalin (NGAL) and cognitive domains in late-life depression

Naude, P. J. W., den Boer, J. A., Comijs, H. C., Bosker, F. J., Zuidersma, M., Groenewold, N. A., De Deyn, P. P., Luiten, P. G. M., Eisel, U. L. M. & Oude Voshaar, R. C., Oct-2014, In : Psychoneuroendocrinology. 48, p. 169-177 9 p.

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  • Sex-specific associations between Neutrophil Gelatinase-Associated Lipocalin

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DOI

BACKGROUND: Although it is well established that late-life depression is associated with both systemic low-graded inflammation and cognitive impairment, the relation between inflammation and cognition in depressed older persons is still equivocal. The objective of this study is to examine the association between plasma Neutrophil Gelatinase-Associated Lipocalin (NGAL) concentrations and cognitive functioning in late-life depression, including the potentially moderating role of sex.

METHODS: A total of 369 depressed older persons (≥60 years) from The Netherlands study of Depression in Older persons (NESDO) were included. Four cognitive domains, i.e. verbal memory, processing speed, interference control and attention were assessed with three cognitive tests (Stroop test, Wais Digit span test, and Rey's verbal learning test). Multiple linear regression analyses were applied with the four cognitive domains as dependent variables adjusted for confounders.

RESULTS: The association between NGAL levels and specific cognitive domains were sex-specific. In women, higher NGAL levels were associated with impaired verbal memory and lower processing speed. In men, higher NGAL levels were associated with worse interference control. Higher NGAL levels were not associated with attention. No sex-specific associations of either high sensitivity C-reactive protein (hsCRP) or interleukin-6 (IL-6) with cognitive functioning were found.

CONCLUSION: This study shows sex-specific association of NGAL with cognitive functioning in late-life depression.

Original languageEnglish
Pages (from-to)169-177
Number of pages9
JournalPsychoneuroendocrinology
Volume48
Publication statusPublished - Oct-2014

    Keywords

  • Cognitive impairment, Verbal memory, Executive functioning, NESDO, Inflammation, Lipocalin 2, hsCRP, IL-6, INCREASED PLASMA-LEVELS, ALZHEIMERS-DISEASE, OLDER-ADULTS, INFLAMMATORY MARKERS, LEUKOCYTE ACTIVATION, HIPPOCAMPAL VOLUME, MAJOR DEPRESSION, SYDNEY MEMORY, RISK-FACTORS, DEMENTIA

ID: 15725060