Publication

Serum Calcification Propensity and the Risk of Cardiovascular and All-Cause Mortality in the General Population: The PREVEND Study

NIGRAM2+ consortium, Aug-2020, In : Arteriosclerosis, thrombosis, and vascular biology. 40, 8, p. 1942-1951 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

NIGRAM2+ consortium (2020). Serum Calcification Propensity and the Risk of Cardiovascular and All-Cause Mortality in the General Population: The PREVEND Study. Arteriosclerosis, thrombosis, and vascular biology, 40(8), 1942-1951. https://doi.org/10.1161/ATVBAHA.120.314187

Author

NIGRAM2+ consortium. / Serum Calcification Propensity and the Risk of Cardiovascular and All-Cause Mortality in the General Population : The PREVEND Study. In: Arteriosclerosis, thrombosis, and vascular biology. 2020 ; Vol. 40, No. 8. pp. 1942-1951.

Harvard

NIGRAM2+ consortium 2020, 'Serum Calcification Propensity and the Risk of Cardiovascular and All-Cause Mortality in the General Population: The PREVEND Study', Arteriosclerosis, thrombosis, and vascular biology, vol. 40, no. 8, pp. 1942-1951. https://doi.org/10.1161/ATVBAHA.120.314187

Standard

Serum Calcification Propensity and the Risk of Cardiovascular and All-Cause Mortality in the General Population : The PREVEND Study. / NIGRAM2+ consortium.

In: Arteriosclerosis, thrombosis, and vascular biology, Vol. 40, No. 8, 08.2020, p. 1942-1951.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

NIGRAM2+ consortium. Serum Calcification Propensity and the Risk of Cardiovascular and All-Cause Mortality in the General Population: The PREVEND Study. Arteriosclerosis, thrombosis, and vascular biology. 2020 Aug;40(8):1942-1951. https://doi.org/10.1161/ATVBAHA.120.314187


BibTeX

@article{4d98d49c777947139c569d9fed73f31a,
title = "Serum Calcification Propensity and the Risk of Cardiovascular and All-Cause Mortality in the General Population: The PREVEND Study",
abstract = "Objective: Vascular calcification contributes to the cause of cardiovascular disease. The calciprotein particle maturation time (T50) in serum, a measure of calcification propensity, has been linked with adverse outcomes in patients with chronic kidney disease, but its role in the general population is unclear. We investigated whether serum T50 is associated with cardiovascular mortality in a large general population-based cohort. Approach and Results: The relationship between serum T50 and cardiovascular mortality was studied in 6231 participants of the PREVEND (Prevention of Renal and Vascular End-Stage Disease) cohort. All-cause mortality was the secondary outcome. Mean (±SD) age was 53±12 years, 50% were male, and mean serum T50 was 329±58 minutes. A shorter serum T50 is indicative of a higher calcification propensity. Serum T50 was inversely associated with circulating phosphate, age, estimated glomerular filtration rate, and alcohol consumption, whereas plasma magnesium was positively associated with serum T50 (P<0.001, total multivariable model R2=0.281). During median (interquartile range) follow-up for 8.3 (7.8-8.9) years, 364 patients died (5.8%), of whom 95 (26.1%) died from a cardiovascular cause. In multivariable Cox proportional hazard models, each 60 minutes decrease in serum T50 was independently associated with a higher risk of cardiovascular mortality (fully adjusted hazard ratio [95% CI], 1.22 [1.04-1.36], P=0.021). This association was modified by diabetes mellitus; stratified analysis indicated a more pronounced association in individuals with diabetes mellitus. Conclusions: Serum T50 is independently associated with an increased risk of cardiovascular mortality in the general population and thus may be an early and potentially modifiable risk marker for cardiovascular mortality.",
author = "{NIGRAM2+ consortium} and Coby Eelderink and {Te Velde-Keyzer}, {Charlotte A} and Frenay, {Anne-Roos S} and Vermeulen, {Emma A} and Matthias Bachtler and Parisa Aghagolzadeh and {van Dijk}, {Peter R} and Gansevoort, {Ronald T} and Vervloet, {Marc G} and Jan-Luuk Hillebrands and Bakker, {Stephan J L} and {van Goor}, Harry and Andreas Pasch and {de Borst}, {Martin H}",
year = "2020",
month = aug,
doi = "10.1161/ATVBAHA.120.314187",
language = "English",
volume = "40",
pages = "1942--1951",
journal = "Arteriosclerosis thrombosis and vascular biology",
issn = "1079-5642",
publisher = "LIPPINCOTT WILLIAMS & WILKINS",
number = "8",

}

RIS

TY - JOUR

T1 - Serum Calcification Propensity and the Risk of Cardiovascular and All-Cause Mortality in the General Population

T2 - The PREVEND Study

AU - NIGRAM2+ consortium

AU - Eelderink, Coby

AU - Te Velde-Keyzer, Charlotte A

AU - Frenay, Anne-Roos S

AU - Vermeulen, Emma A

AU - Bachtler, Matthias

AU - Aghagolzadeh, Parisa

AU - van Dijk, Peter R

AU - Gansevoort, Ronald T

AU - Vervloet, Marc G

AU - Hillebrands, Jan-Luuk

AU - Bakker, Stephan J L

AU - van Goor, Harry

AU - Pasch, Andreas

AU - de Borst, Martin H

PY - 2020/8

Y1 - 2020/8

N2 - Objective: Vascular calcification contributes to the cause of cardiovascular disease. The calciprotein particle maturation time (T50) in serum, a measure of calcification propensity, has been linked with adverse outcomes in patients with chronic kidney disease, but its role in the general population is unclear. We investigated whether serum T50 is associated with cardiovascular mortality in a large general population-based cohort. Approach and Results: The relationship between serum T50 and cardiovascular mortality was studied in 6231 participants of the PREVEND (Prevention of Renal and Vascular End-Stage Disease) cohort. All-cause mortality was the secondary outcome. Mean (±SD) age was 53±12 years, 50% were male, and mean serum T50 was 329±58 minutes. A shorter serum T50 is indicative of a higher calcification propensity. Serum T50 was inversely associated with circulating phosphate, age, estimated glomerular filtration rate, and alcohol consumption, whereas plasma magnesium was positively associated with serum T50 (P<0.001, total multivariable model R2=0.281). During median (interquartile range) follow-up for 8.3 (7.8-8.9) years, 364 patients died (5.8%), of whom 95 (26.1%) died from a cardiovascular cause. In multivariable Cox proportional hazard models, each 60 minutes decrease in serum T50 was independently associated with a higher risk of cardiovascular mortality (fully adjusted hazard ratio [95% CI], 1.22 [1.04-1.36], P=0.021). This association was modified by diabetes mellitus; stratified analysis indicated a more pronounced association in individuals with diabetes mellitus. Conclusions: Serum T50 is independently associated with an increased risk of cardiovascular mortality in the general population and thus may be an early and potentially modifiable risk marker for cardiovascular mortality.

AB - Objective: Vascular calcification contributes to the cause of cardiovascular disease. The calciprotein particle maturation time (T50) in serum, a measure of calcification propensity, has been linked with adverse outcomes in patients with chronic kidney disease, but its role in the general population is unclear. We investigated whether serum T50 is associated with cardiovascular mortality in a large general population-based cohort. Approach and Results: The relationship between serum T50 and cardiovascular mortality was studied in 6231 participants of the PREVEND (Prevention of Renal and Vascular End-Stage Disease) cohort. All-cause mortality was the secondary outcome. Mean (±SD) age was 53±12 years, 50% were male, and mean serum T50 was 329±58 minutes. A shorter serum T50 is indicative of a higher calcification propensity. Serum T50 was inversely associated with circulating phosphate, age, estimated glomerular filtration rate, and alcohol consumption, whereas plasma magnesium was positively associated with serum T50 (P<0.001, total multivariable model R2=0.281). During median (interquartile range) follow-up for 8.3 (7.8-8.9) years, 364 patients died (5.8%), of whom 95 (26.1%) died from a cardiovascular cause. In multivariable Cox proportional hazard models, each 60 minutes decrease in serum T50 was independently associated with a higher risk of cardiovascular mortality (fully adjusted hazard ratio [95% CI], 1.22 [1.04-1.36], P=0.021). This association was modified by diabetes mellitus; stratified analysis indicated a more pronounced association in individuals with diabetes mellitus. Conclusions: Serum T50 is independently associated with an increased risk of cardiovascular mortality in the general population and thus may be an early and potentially modifiable risk marker for cardiovascular mortality.

U2 - 10.1161/ATVBAHA.120.314187

DO - 10.1161/ATVBAHA.120.314187

M3 - Article

C2 - 32493170

VL - 40

SP - 1942

EP - 1951

JO - Arteriosclerosis thrombosis and vascular biology

JF - Arteriosclerosis thrombosis and vascular biology

SN - 1079-5642

IS - 8

ER -

ID: 126800801