Sequential uniform designs for fingerprints development of Ginkgo biloba extracts by capillary electrophoresisJi, Y. B., Alaerts, G., Xu, C. J., Hu, Y. Z. & Vander Heyden, Y., 22-Sep-2006, In : Journal of Chromatography A. 1128, 1-2, p. 273-281 9 p.
Research output: Contribution to journal › Article › Academic › peer-review
A sequential procedure for the method of development of fingerprints based on a uniform design approach has been described in this paper. The sequential uniform design is used to reach the global optimum for a separation. The procedure is illustrated through developing the fingerprint of a Ginkgo biloba extract by capillary electrophoresis (CE) with diode array detection (DAD). The local overlap index (LOVI) is proposed as a criterion to evaluate the separation quality of two-dimensional hyphenated data in the optimization process. The successful application of the described techniques, including a sequential procedure, the CE-DAD hyphenated method and the LOVI criterion, shows their practicality in the fingerprint development of herbal medicines. However, some critical remarks on their use can also be made.
|Number of pages||9|
|Journal||Journal of Chromatography A|
|Publication status||Published - 22-Sep-2006|
- CE fingerprint, Ginkgo biloba, Local overlap index, Sequential uniform design, Two-dimensional data