Publication

Sequential uniform designs for fingerprints development of Ginkgo biloba extracts by capillary electrophoresis

Ji, Y. B., Alaerts, G., Xu, C. J., Hu, Y. Z. & Vander Heyden, Y., 22-Sep-2006, In : Journal of Chromatography A. 1128, 1-2, p. 273-281 9 p.

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  • Sequential uniform designs for fingerprints development of Ginkgo biloba extracts by capillary electrophoresis

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DOI

  • Yi Bing Ji
  • Goedele Alaerts
  • Cheng Jian Xu
  • Yu Zhu Hu
  • Yvan Vander Heyden

A sequential procedure for the method of development of fingerprints based on a uniform design approach has been described in this paper. The sequential uniform design is used to reach the global optimum for a separation. The procedure is illustrated through developing the fingerprint of a Ginkgo biloba extract by capillary electrophoresis (CE) with diode array detection (DAD). The local overlap index (LOVI) is proposed as a criterion to evaluate the separation quality of two-dimensional hyphenated data in the optimization process. The successful application of the described techniques, including a sequential procedure, the CE-DAD hyphenated method and the LOVI criterion, shows their practicality in the fingerprint development of herbal medicines. However, some critical remarks on their use can also be made.

Original languageEnglish
Pages (from-to)273-281
Number of pages9
JournalJournal of Chromatography A
Volume1128
Issue number1-2
Publication statusPublished - 22-Sep-2006

    Keywords

  • CE fingerprint, Ginkgo biloba, Local overlap index, Sequential uniform design, Two-dimensional data

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