Publication

Sentinel Node Biopsy for Melanoma Patients with a Local Recurrence or In-Transit Metastasis

Nijhuis, A. A. G., Santos Filho, I. D. D. A. O., Holtkamp, L. H. J., Uren, R. F., Thompson, J. F. & Nieweg, O. E., Feb-2020, In : Annals of Surgical Oncology. 27, 2, p. 561-568 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Nijhuis, A. A. G., Santos Filho, I. D. D. A. O., Holtkamp, L. H. J., Uren, R. F., Thompson, J. F., & Nieweg, O. E. (2020). Sentinel Node Biopsy for Melanoma Patients with a Local Recurrence or In-Transit Metastasis. Annals of Surgical Oncology, 27(2), 561-568. https://doi.org/10.1245/s10434-019-07699-9

Author

Nijhuis, Amanda A. G. ; Santos Filho, Ivan D. de A. O. ; Holtkamp, Lodewijka H. J. ; Uren, Roger F. ; Thompson, John F. ; Nieweg, Omgo E. / Sentinel Node Biopsy for Melanoma Patients with a Local Recurrence or In-Transit Metastasis. In: Annals of Surgical Oncology. 2020 ; Vol. 27, No. 2. pp. 561-568.

Harvard

Nijhuis, AAG, Santos Filho, IDDAO, Holtkamp, LHJ, Uren, RF, Thompson, JF & Nieweg, OE 2020, 'Sentinel Node Biopsy for Melanoma Patients with a Local Recurrence or In-Transit Metastasis', Annals of Surgical Oncology, vol. 27, no. 2, pp. 561-568. https://doi.org/10.1245/s10434-019-07699-9

Standard

Sentinel Node Biopsy for Melanoma Patients with a Local Recurrence or In-Transit Metastasis. / Nijhuis, Amanda A. G.; Santos Filho, Ivan D. de A. O.; Holtkamp, Lodewijka H. J.; Uren, Roger F.; Thompson, John F.; Nieweg, Omgo E.

In: Annals of Surgical Oncology, Vol. 27, No. 2, 02.2020, p. 561-568.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Nijhuis AAG, Santos Filho IDDAO, Holtkamp LHJ, Uren RF, Thompson JF, Nieweg OE. Sentinel Node Biopsy for Melanoma Patients with a Local Recurrence or In-Transit Metastasis. Annals of Surgical Oncology. 2020 Feb;27(2):561-568. https://doi.org/10.1245/s10434-019-07699-9


BibTeX

@article{ddf10b5d44c945c69a3002755b7eb332,
title = "Sentinel Node Biopsy for Melanoma Patients with a Local Recurrence or In-Transit Metastasis",
abstract = "Background. Sentinel node (SN) biopsy (SNB) is not routinely performed for melanoma patients with local recurrence (LR) or in-transit metastasis (ITM). This study aimed to describe the technique, findings, and prognostic value of this procedure, and the outcome for such patients at our institution.Methods. Prospectively collected data were obtained from the Melanoma Institute Australia database. Patients who had SNB for LR or ITM between 1992 and 2015 were included in the study. Patient and primary tumor characteristics, lymphoscintigrams, SNB results, and follow-up data were analyzed.Results. Overall, 7999 patients underwent SNB, 128 (1.6{\%}) of whom met the selection criteria. The SNB procedure was performed for 85 of 1516 patients with LR (6{\%}), 17 of 1671 patients with ITM from a known primary tumor (1{\%}), and 26 of 170 patients who presented with ITM from an unknown primary site (15{\%}). The SN identification rate was 100{\%}. Metastatic melanoma was identified in an SN from 16 of the 128 patients (13{\%}). Follow-up data were available for 114 patients. The false-negative rate was 27{\%}. The SN-positive patients had significantly worse overall survival than the SN-negative patients, with respective 5-year survival rates of 54{\%} and 81{\%} (P = 0.01).Conclusion. The SNB procedure was performed infrequently for LR or ITM. The SNs were positive for 13{\%} of the patients with LR or ITM. Positive SNs were associated with worse overall survival. Despite the false-negative rate of 27{\%}, the procedure yielded information that was relevant for staging and prognosis. The SNB procedure should be considered for patients with LR or ITM.",
keywords = "STAGE-III, MULTICENTER, DISSECTION, PROGNOSIS",
author = "Nijhuis, {Amanda A. G.} and {Santos Filho}, {Ivan D. de A. O.} and Holtkamp, {Lodewijka H. J.} and Uren, {Roger F.} and Thompson, {John F.} and Nieweg, {Omgo E.}",
year = "2020",
month = "2",
doi = "10.1245/s10434-019-07699-9",
language = "English",
volume = "27",
pages = "561--568",
journal = "Annals of Surgical Oncology",
issn = "1068-9265",
publisher = "SPRINGER",
number = "2",

}

RIS

TY - JOUR

T1 - Sentinel Node Biopsy for Melanoma Patients with a Local Recurrence or In-Transit Metastasis

AU - Nijhuis, Amanda A. G.

AU - Santos Filho, Ivan D. de A. O.

AU - Holtkamp, Lodewijka H. J.

AU - Uren, Roger F.

AU - Thompson, John F.

AU - Nieweg, Omgo E.

PY - 2020/2

Y1 - 2020/2

N2 - Background. Sentinel node (SN) biopsy (SNB) is not routinely performed for melanoma patients with local recurrence (LR) or in-transit metastasis (ITM). This study aimed to describe the technique, findings, and prognostic value of this procedure, and the outcome for such patients at our institution.Methods. Prospectively collected data were obtained from the Melanoma Institute Australia database. Patients who had SNB for LR or ITM between 1992 and 2015 were included in the study. Patient and primary tumor characteristics, lymphoscintigrams, SNB results, and follow-up data were analyzed.Results. Overall, 7999 patients underwent SNB, 128 (1.6%) of whom met the selection criteria. The SNB procedure was performed for 85 of 1516 patients with LR (6%), 17 of 1671 patients with ITM from a known primary tumor (1%), and 26 of 170 patients who presented with ITM from an unknown primary site (15%). The SN identification rate was 100%. Metastatic melanoma was identified in an SN from 16 of the 128 patients (13%). Follow-up data were available for 114 patients. The false-negative rate was 27%. The SN-positive patients had significantly worse overall survival than the SN-negative patients, with respective 5-year survival rates of 54% and 81% (P = 0.01).Conclusion. The SNB procedure was performed infrequently for LR or ITM. The SNs were positive for 13% of the patients with LR or ITM. Positive SNs were associated with worse overall survival. Despite the false-negative rate of 27%, the procedure yielded information that was relevant for staging and prognosis. The SNB procedure should be considered for patients with LR or ITM.

AB - Background. Sentinel node (SN) biopsy (SNB) is not routinely performed for melanoma patients with local recurrence (LR) or in-transit metastasis (ITM). This study aimed to describe the technique, findings, and prognostic value of this procedure, and the outcome for such patients at our institution.Methods. Prospectively collected data were obtained from the Melanoma Institute Australia database. Patients who had SNB for LR or ITM between 1992 and 2015 were included in the study. Patient and primary tumor characteristics, lymphoscintigrams, SNB results, and follow-up data were analyzed.Results. Overall, 7999 patients underwent SNB, 128 (1.6%) of whom met the selection criteria. The SNB procedure was performed for 85 of 1516 patients with LR (6%), 17 of 1671 patients with ITM from a known primary tumor (1%), and 26 of 170 patients who presented with ITM from an unknown primary site (15%). The SN identification rate was 100%. Metastatic melanoma was identified in an SN from 16 of the 128 patients (13%). Follow-up data were available for 114 patients. The false-negative rate was 27%. The SN-positive patients had significantly worse overall survival than the SN-negative patients, with respective 5-year survival rates of 54% and 81% (P = 0.01).Conclusion. The SNB procedure was performed infrequently for LR or ITM. The SNs were positive for 13% of the patients with LR or ITM. Positive SNs were associated with worse overall survival. Despite the false-negative rate of 27%, the procedure yielded information that was relevant for staging and prognosis. The SNB procedure should be considered for patients with LR or ITM.

KW - STAGE-III

KW - MULTICENTER

KW - DISSECTION

KW - PROGNOSIS

U2 - 10.1245/s10434-019-07699-9

DO - 10.1245/s10434-019-07699-9

M3 - Article

VL - 27

SP - 561

EP - 568

JO - Annals of Surgical Oncology

JF - Annals of Surgical Oncology

SN - 1068-9265

IS - 2

ER -

ID: 113510336