Publication

Sensitivity and accuracy of volumetry of pulmonary nodules on low-dose 16- and 64-row multi-detector CT: an anthropomorphic phantom study

Xie, X., Zhao, Y., Snijder, R. A., van Ooijen, P. M., de Jong, P. A., Oudkerk, M., de Bock, G. H., Vliegenthart, R. & Greuter, M. J., Jan-2013, In : European Radiology. 23, 1, p. 139-147 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Xie, X., Zhao, Y., Snijder, R. A., van Ooijen, P. M., de Jong, P. A., Oudkerk, M., ... Greuter, M. J. (2013). Sensitivity and accuracy of volumetry of pulmonary nodules on low-dose 16- and 64-row multi-detector CT: an anthropomorphic phantom study. European Radiology, 23(1), 139-147. https://doi.org/10.1007/s00330-012-2570-7

Author

Xie, X. ; Zhao, Yingru ; Snijder, R.A. ; van Ooijen, P.M. ; de Jong, P.A. ; Oudkerk, M. ; de Bock, G.H. ; Vliegenthart, R. ; Greuter, M.J. / Sensitivity and accuracy of volumetry of pulmonary nodules on low-dose 16- and 64-row multi-detector CT : an anthropomorphic phantom study. In: European Radiology. 2013 ; Vol. 23, No. 1. pp. 139-147.

Harvard

Xie, X, Zhao, Y, Snijder, RA, van Ooijen, PM, de Jong, PA, Oudkerk, M, de Bock, GH, Vliegenthart, R & Greuter, MJ 2013, 'Sensitivity and accuracy of volumetry of pulmonary nodules on low-dose 16- and 64-row multi-detector CT: an anthropomorphic phantom study', European Radiology, vol. 23, no. 1, pp. 139-147. https://doi.org/10.1007/s00330-012-2570-7

Standard

Sensitivity and accuracy of volumetry of pulmonary nodules on low-dose 16- and 64-row multi-detector CT : an anthropomorphic phantom study. / Xie, X.; Zhao, Yingru; Snijder, R.A.; van Ooijen, P.M.; de Jong, P.A.; Oudkerk, M.; de Bock, G.H.; Vliegenthart, R.; Greuter, M.J.

In: European Radiology, Vol. 23, No. 1, 01.2013, p. 139-147.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Xie X, Zhao Y, Snijder RA, van Ooijen PM, de Jong PA, Oudkerk M et al. Sensitivity and accuracy of volumetry of pulmonary nodules on low-dose 16- and 64-row multi-detector CT: an anthropomorphic phantom study. European Radiology. 2013 Jan;23(1):139-147. https://doi.org/10.1007/s00330-012-2570-7


BibTeX

@article{72e40526c7d64b8fa7598bfd9d26667d,
title = "Sensitivity and accuracy of volumetry of pulmonary nodules on low-dose 16- and 64-row multi-detector CT: an anthropomorphic phantom study",
abstract = "To assess the sensitivity of detection and accuracy of volumetry by manual and semi-automated quantification of artificial pulmonary nodules in an anthropomorphic thoracic phantom on low-dose CT.Fifteen artificial spherical nodules (diameter 3, 5, 8, 10 and 12 mm; CT densities -800, -630 and +100 HU) were randomly placed inside an anthropomorphic thoracic phantom. The phantom was examined on 16- and 64-row multidetector CT with a low-dose protocol. Two independent blinded observers screened for pulmonary nodules. Nodule diameter was measured manually, and volume calculated. For solid nodules (+100 HU), diameter and volume were also evaluated by semi-automated software. Differences in observed volumes between the manual and semi-automated method were evaluated by a t-test.Sensitivity was 100 {\%} for all nodules of > 5 mm and larger, 60-80 {\%} for solid and 0-20 {\%} for non-solid 3-mm nodules. No false-positive nodules but high inter-observer reliability and inter-technique correlation were found. Volume was underestimated manually by 24.1 +/- 14.0 {\%} for nodules of any density, and 26.4 +/- 15.5 {\%} for solid nodules, compared with 7.6 +/- 8.5 {\%} (P <0.01) semi-automatically.In an anthropomorphic phantom study, the sensitivity of detection is 100 {\%} for nodules of > 5 mm in diameter. Semi-automated volumetry yielded more accurate nodule volumes than manual measurements.aEuro cent Computed tomography has become the definitive investigation of the chest.aEuro cent Low-dose CT techniques have recently been introduced.aEuro cent Low-dose CT is reliable for detecting spherical pulmonary nodules of > 5 mm.aEuro cent Semi-automated volumetry is more accurate than manual measurement for pulmonary nodules.aEuro cent No difference in the accuracy of volumetry was found between 16- and 64- MDCT.",
keywords = "Lung neoplasms, Mass screening, Pulmonary nodule, Phantoms, Imaging, Tomography, X-ray computed, LUNG NODULES, RECONSTRUCTION PARAMETERS, COMPUTED-TOMOGRAPHY, CANCER-MORTALITY, THORACIC CT, SEGMENTATION, TUMORS",
author = "X. Xie and Yingru Zhao and R.A. Snijder and {van Ooijen}, P.M. and {de Jong}, P.A. and M. Oudkerk and {de Bock}, G.H. and R. Vliegenthart and M.J. Greuter",
year = "2013",
month = "1",
doi = "10.1007/s00330-012-2570-7",
language = "English",
volume = "23",
pages = "139--147",
journal = "European Radiology",
issn = "0938-7994",
publisher = "SPRINGER",
number = "1",

}

RIS

TY - JOUR

T1 - Sensitivity and accuracy of volumetry of pulmonary nodules on low-dose 16- and 64-row multi-detector CT

T2 - an anthropomorphic phantom study

AU - Xie, X.

AU - Zhao, Yingru

AU - Snijder, R.A.

AU - van Ooijen, P.M.

AU - de Jong, P.A.

AU - Oudkerk, M.

AU - de Bock, G.H.

AU - Vliegenthart, R.

AU - Greuter, M.J.

PY - 2013/1

Y1 - 2013/1

N2 - To assess the sensitivity of detection and accuracy of volumetry by manual and semi-automated quantification of artificial pulmonary nodules in an anthropomorphic thoracic phantom on low-dose CT.Fifteen artificial spherical nodules (diameter 3, 5, 8, 10 and 12 mm; CT densities -800, -630 and +100 HU) were randomly placed inside an anthropomorphic thoracic phantom. The phantom was examined on 16- and 64-row multidetector CT with a low-dose protocol. Two independent blinded observers screened for pulmonary nodules. Nodule diameter was measured manually, and volume calculated. For solid nodules (+100 HU), diameter and volume were also evaluated by semi-automated software. Differences in observed volumes between the manual and semi-automated method were evaluated by a t-test.Sensitivity was 100 % for all nodules of > 5 mm and larger, 60-80 % for solid and 0-20 % for non-solid 3-mm nodules. No false-positive nodules but high inter-observer reliability and inter-technique correlation were found. Volume was underestimated manually by 24.1 +/- 14.0 % for nodules of any density, and 26.4 +/- 15.5 % for solid nodules, compared with 7.6 +/- 8.5 % (P <0.01) semi-automatically.In an anthropomorphic phantom study, the sensitivity of detection is 100 % for nodules of > 5 mm in diameter. Semi-automated volumetry yielded more accurate nodule volumes than manual measurements.aEuro cent Computed tomography has become the definitive investigation of the chest.aEuro cent Low-dose CT techniques have recently been introduced.aEuro cent Low-dose CT is reliable for detecting spherical pulmonary nodules of > 5 mm.aEuro cent Semi-automated volumetry is more accurate than manual measurement for pulmonary nodules.aEuro cent No difference in the accuracy of volumetry was found between 16- and 64- MDCT.

AB - To assess the sensitivity of detection and accuracy of volumetry by manual and semi-automated quantification of artificial pulmonary nodules in an anthropomorphic thoracic phantom on low-dose CT.Fifteen artificial spherical nodules (diameter 3, 5, 8, 10 and 12 mm; CT densities -800, -630 and +100 HU) were randomly placed inside an anthropomorphic thoracic phantom. The phantom was examined on 16- and 64-row multidetector CT with a low-dose protocol. Two independent blinded observers screened for pulmonary nodules. Nodule diameter was measured manually, and volume calculated. For solid nodules (+100 HU), diameter and volume were also evaluated by semi-automated software. Differences in observed volumes between the manual and semi-automated method were evaluated by a t-test.Sensitivity was 100 % for all nodules of > 5 mm and larger, 60-80 % for solid and 0-20 % for non-solid 3-mm nodules. No false-positive nodules but high inter-observer reliability and inter-technique correlation were found. Volume was underestimated manually by 24.1 +/- 14.0 % for nodules of any density, and 26.4 +/- 15.5 % for solid nodules, compared with 7.6 +/- 8.5 % (P <0.01) semi-automatically.In an anthropomorphic phantom study, the sensitivity of detection is 100 % for nodules of > 5 mm in diameter. Semi-automated volumetry yielded more accurate nodule volumes than manual measurements.aEuro cent Computed tomography has become the definitive investigation of the chest.aEuro cent Low-dose CT techniques have recently been introduced.aEuro cent Low-dose CT is reliable for detecting spherical pulmonary nodules of > 5 mm.aEuro cent Semi-automated volumetry is more accurate than manual measurement for pulmonary nodules.aEuro cent No difference in the accuracy of volumetry was found between 16- and 64- MDCT.

KW - Lung neoplasms

KW - Mass screening

KW - Pulmonary nodule

KW - Phantoms

KW - Imaging

KW - Tomography

KW - X-ray computed

KW - LUNG NODULES

KW - RECONSTRUCTION PARAMETERS

KW - COMPUTED-TOMOGRAPHY

KW - CANCER-MORTALITY

KW - THORACIC CT

KW - SEGMENTATION

KW - TUMORS

U2 - 10.1007/s00330-012-2570-7

DO - 10.1007/s00330-012-2570-7

M3 - Article

VL - 23

SP - 139

EP - 147

JO - European Radiology

JF - European Radiology

SN - 0938-7994

IS - 1

ER -

ID: 2387155