Sensitivity and accuracy of volumetry of pulmonary nodules on low-dose 16- and 64-row multi-detector CT: an anthropomorphic phantom study

Xie, X., Zhao, Y., Snijder, R. A., van Ooijen, P. M., de Jong, P. A., Oudkerk, M., de Bock, G. H., Vliegenthart, R. & Greuter, M. J., Jan-2013, In : European Radiology. 23, 1, p. 139-147 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

To assess the sensitivity of detection and accuracy of volumetry by manual and semi-automated quantification of artificial pulmonary nodules in an anthropomorphic thoracic phantom on low-dose CT.

Fifteen artificial spherical nodules (diameter 3, 5, 8, 10 and 12 mm; CT densities -800, -630 and +100 HU) were randomly placed inside an anthropomorphic thoracic phantom. The phantom was examined on 16- and 64-row multidetector CT with a low-dose protocol. Two independent blinded observers screened for pulmonary nodules. Nodule diameter was measured manually, and volume calculated. For solid nodules (+100 HU), diameter and volume were also evaluated by semi-automated software. Differences in observed volumes between the manual and semi-automated method were evaluated by a t-test.

Sensitivity was 100 % for all nodules of > 5 mm and larger, 60-80 % for solid and 0-20 % for non-solid 3-mm nodules. No false-positive nodules but high inter-observer reliability and inter-technique correlation were found. Volume was underestimated manually by 24.1 +/- 14.0 % for nodules of any density, and 26.4 +/- 15.5 % for solid nodules, compared with 7.6 +/- 8.5 % (P <0.01) semi-automatically.

In an anthropomorphic phantom study, the sensitivity of detection is 100 % for nodules of > 5 mm in diameter. Semi-automated volumetry yielded more accurate nodule volumes than manual measurements.

aEuro cent Computed tomography has become the definitive investigation of the chest.

aEuro cent Low-dose CT techniques have recently been introduced.

aEuro cent Low-dose CT is reliable for detecting spherical pulmonary nodules of > 5 mm.

aEuro cent Semi-automated volumetry is more accurate than manual measurement for pulmonary nodules.

aEuro cent No difference in the accuracy of volumetry was found between 16- and 64- MDCT.

Original languageEnglish
Pages (from-to)139-147
Number of pages9
JournalEuropean Radiology
Issue number1
Publication statusPublished - Jan-2013


  • Lung neoplasms, Mass screening, Pulmonary nodule, Phantoms, Imaging, Tomography, X-ray computed, LUNG NODULES, RECONSTRUCTION PARAMETERS, COMPUTED-TOMOGRAPHY, CANCER-MORTALITY, THORACIC CT, SEGMENTATION, TUMORS

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