Senescent Cells in Cancer Therapy: Friends or Foes?

Wang, B., Kohli, J. & Demaria, M., Oct-2020, In : Trends in cancer. 6, 10, p. 838-857 20 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Several cancer interventions induce DNA damage and promote senescence in cancer and nonmalignant cells. Senescent cells secrete a collection of proinflammatory factors collectively termed the senescence-associated secretory phenotype (SASP). SASP factors are able to potentiate various aspects of tumorigenesis, including proliferation, metastasis, and immunosuppression. Moreover, the accumulation and persistence of therapy-induced senescent cells can promote tissue dysfunction and the early onset of various age-related symptoms in treated cancer patients. Here, we review in detail the mechanisms by which cellular senescence contributes to cancer development and the side effects of cancer therapies. We also review how pharmacological interventions to eliminate senescent cells or inhibit SASP production can mitigate these negative effects and propose therapeutic strategies based on the age of the patient.

Original languageEnglish
Pages (from-to)838-857
Number of pages20
JournalTrends in cancer
Issue number10
Early online date29-May-2020
Publication statusPublished - Oct-2020

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