Publication

Self-Assembly Can Direct Dynamic Covalent Bond Formation Towards Diversity or Specificity

Komaromy, D., Stuart, M. C. A., Monréal Santiago, G., Tezcan, M., Krasnikov, V. V. & Otto, S., 3-May-2017, In : Journal of the American Chemical Society. 139, 17, p. 6234-6241

Research output: Contribution to journalArticleAcademicpeer-review

With the advent of reversible covalent chemistry the study of the interplay between covalent bond formation and non-covalent interactions has become increasingly relevant. Here we report that the interplay between reversible disulfide chemistry and self-assembly can give rise either to molecular diversity, i.e. the emergence of a unprecedentedly large range of macrocycles or to molecular specificity, i.e. the autocatalytic emergence of a single species. The two phenomena are the result of two different modes of self-assembly, demonstrating that control over self-assembly pathways can enable control over covalent bond formation.

Original languageEnglish
Pages (from-to)6234-6241
JournalJournal of the American Chemical Society
Volume139
Issue number17
Early online date11-Apr-2017
Publication statusPublished - 3-May-2017

    Keywords

  • self-assembly, covalent bonds, diversity, specificity, non-covalent interactions, COMBINATORIAL LIBRARIES, MORPHOLOGICAL TRANSFORMATION, SUPRAMOLECULAR POLYMERS, GUEST BINDING, CHEMISTRY, AMPLIFICATION, SURFACTANTS, EMERGENCE, SELECTION, SHAPE

Download statistics

No data available

ID: 41413254