Self-Assembly Can Direct Dynamic Covalent Bond Formation Towards Diversity or SpecificityKomaromy, D., Stuart, M. C. A., Monréal Santiago, G., Tezcan, M., Krasnikov, V. V. & Otto, S., 3-May-2017, In : Journal of the American Chemical Society. 139, 17, p. 6234-6241
Research output: Contribution to journal › Article › Academic › peer-review
With the advent of reversible covalent chemistry the study of the interplay between covalent bond formation and non-covalent interactions has become increasingly relevant. Here we report that the interplay between reversible disulfide chemistry and self-assembly can give rise either to molecular diversity, i.e. the emergence of a unprecedentedly large range of macrocycles or to molecular specificity, i.e. the autocatalytic emergence of a single species. The two phenomena are the result of two different modes of self-assembly, demonstrating that control over self-assembly pathways can enable control over covalent bond formation.
|Journal||Journal of the American Chemical Society|
|Early online date||11-Apr-2017|
|Publication status||Published - 3-May-2017|
- self-assembly, covalent bonds, diversity, specificity, non-covalent interactions, COMBINATORIAL LIBRARIES, MORPHOLOGICAL TRANSFORMATION, SUPRAMOLECULAR POLYMERS, GUEST BINDING, CHEMISTRY, AMPLIFICATION, SURFACTANTS, EMERGENCE, SELECTION, SHAPE