Publication

Seasonal human coronaviruses respiratory tract infection in recipients of allogeneic hematopoietic stem cell transplantation

Infectious Diseases Working Party of the European Society for Blood and Marrow Transplantation and Infectious Complications Subcommittee of the Spanish Hematopoietic Stem Cell Transplantation and Cell Therapy Group (GETH), Piñana, J. L., Xhaard, A., Tridello, G., Passweg, J., Kozijn, A., Polverelli, N., Heras, I., Perez, A., Sanz, J., Berghuis, D., Vázquez, L., Suárez-Lledó, M., Itäla-Remes, M., Ozcelik, T., Iturrate Basarán, I., Karakukcu, M., Al Zahrani, M., Choi, G., Cuesta Casas, M. A., Batlle Massana, M., Viviana, A., Blijlevens, N., Ganser, A., Kuskonmaz, B., Labussière-Wallet, H., Shaw, P. J., Arzu Yegin, Z., González-Vicent, M., Rocha, V., Ferster, A., Knelange, N., Navarro, D., Mikulska, M., de la Camara, R. & Styczynski, J., 29-Aug-2020, In : The Journal of Infectious Diseases.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Infectious Diseases Working Party of the European Society for Blood and Marrow Transplantation and Infectious Complications Subcommittee of the Spanish Hematopoietic Stem Cell Transplantation and Cell Therapy Group (GETH), Piñana, J. L., Xhaard, A., Tridello, G., Passweg, J., Kozijn, A., Polverelli, N., Heras, I., Perez, A., Sanz, J., Berghuis, D., Vázquez, L., Suárez-Lledó, M., Itäla-Remes, M., Ozcelik, T., Iturrate Basarán, I., Karakukcu, M., Al Zahrani, M., Choi, G., ... Styczynski, J. (2020). Seasonal human coronaviruses respiratory tract infection in recipients of allogeneic hematopoietic stem cell transplantation. The Journal of Infectious Diseases. https://doi.org/10.1093/infdis/jiaa553

Author

Infectious Diseases Working Party of the European Society for Blood and Marrow Transplantation and Infectious Complications Subcommittee of the Spanish Hematopoietic Stem Cell Transplantation and Cell Therapy Group (GETH) ; Piñana, Jose Luis ; Xhaard, Aliénor ; Tridello, Gloria ; Passweg, Jakob ; Kozijn, Anne ; Polverelli, Nicola ; Heras, Inmaculada ; Perez, Ariadna ; Sanz, Jaime ; Berghuis, Dagmar ; Vázquez, Lourdes ; Suárez-Lledó, María ; Itäla-Remes, Maija ; Ozcelik, Tulay ; Iturrate Basarán, Isabel ; Karakukcu, Musa ; Al Zahrani, Mohsen ; Choi, Goda ; Cuesta Casas, Marián Angeles ; Batlle Massana, Montserrat ; Viviana, Amato ; Blijlevens, Nicole ; Ganser, Arnold ; Kuskonmaz, Baris ; Labussière-Wallet, Hélène ; Shaw, Peter J ; Arzu Yegin, Zeynep ; González-Vicent, Marta ; Rocha, Vanderson ; Ferster, Alina ; Knelange, Nina ; Navarro, David ; Mikulska, Malgorzata ; de la Camara, Rafael ; Styczynski, Jan. / Seasonal human coronaviruses respiratory tract infection in recipients of allogeneic hematopoietic stem cell transplantation. In: The Journal of Infectious Diseases. 2020.

Harvard

Infectious Diseases Working Party of the European Society for Blood and Marrow Transplantation and Infectious Complications Subcommittee of the Spanish Hematopoietic Stem Cell Transplantation and Cell Therapy Group (GETH), Piñana, JL, Xhaard, A, Tridello, G, Passweg, J, Kozijn, A, Polverelli, N, Heras, I, Perez, A, Sanz, J, Berghuis, D, Vázquez, L, Suárez-Lledó, M, Itäla-Remes, M, Ozcelik, T, Iturrate Basarán, I, Karakukcu, M, Al Zahrani, M, Choi, G, Cuesta Casas, MA, Batlle Massana, M, Viviana, A, Blijlevens, N, Ganser, A, Kuskonmaz, B, Labussière-Wallet, H, Shaw, PJ, Arzu Yegin, Z, González-Vicent, M, Rocha, V, Ferster, A, Knelange, N, Navarro, D, Mikulska, M, de la Camara, R & Styczynski, J 2020, 'Seasonal human coronaviruses respiratory tract infection in recipients of allogeneic hematopoietic stem cell transplantation', The Journal of Infectious Diseases. https://doi.org/10.1093/infdis/jiaa553

Standard

Seasonal human coronaviruses respiratory tract infection in recipients of allogeneic hematopoietic stem cell transplantation. / Infectious Diseases Working Party of the European Society for Blood and Marrow Transplantation and Infectious Complications Subcommittee of the Spanish Hematopoietic Stem Cell Transplantation and Cell Therapy Group (GETH); Piñana, Jose Luis; Xhaard, Aliénor; Tridello, Gloria; Passweg, Jakob; Kozijn, Anne; Polverelli, Nicola; Heras, Inmaculada; Perez, Ariadna; Sanz, Jaime; Berghuis, Dagmar; Vázquez, Lourdes; Suárez-Lledó, María; Itäla-Remes, Maija; Ozcelik, Tulay; Iturrate Basarán, Isabel; Karakukcu, Musa; Al Zahrani, Mohsen; Choi, Goda; Cuesta Casas, Marián Angeles; Batlle Massana, Montserrat; Viviana, Amato; Blijlevens, Nicole; Ganser, Arnold; Kuskonmaz, Baris; Labussière-Wallet, Hélène; Shaw, Peter J; Arzu Yegin, Zeynep; González-Vicent, Marta; Rocha, Vanderson; Ferster, Alina; Knelange, Nina; Navarro, David; Mikulska, Malgorzata; de la Camara, Rafael; Styczynski, Jan.

In: The Journal of Infectious Diseases, 29.08.2020.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Infectious Diseases Working Party of the European Society for Blood and Marrow Transplantation and Infectious Complications Subcommittee of the Spanish Hematopoietic Stem Cell Transplantation and Cell Therapy Group (GETH), Piñana JL, Xhaard A, Tridello G, Passweg J, Kozijn A et al. Seasonal human coronaviruses respiratory tract infection in recipients of allogeneic hematopoietic stem cell transplantation. The Journal of Infectious Diseases. 2020 Aug 29. https://doi.org/10.1093/infdis/jiaa553


BibTeX

@article{da2b524ad07043cf9ec63f295fd9f7ac,
title = "Seasonal human coronaviruses respiratory tract infection in recipients of allogeneic hematopoietic stem cell transplantation",
abstract = "BACKGROUND: Little is known about characteristics of seasonal human coronavirus (HCoV) (NL63, 229E, OC43 and HKU1) after allogeneic stem cell transplantation (allo-HCT).PATIENTS AND METHODS: this is a collaborative Spanish and European bone marrow transplantation groups retrospective multicentre study, which included allo-HCT recipients (adults and children) with upper and/or lower respiratory tract disease (U/LRTD) caused by seasonal HCoV diagnosed through multiplex PCR assays from January 2012 to January 2019.RESULTS: We included 402 allo-HCT recipients who developed 449 HCoV U/LRTD episodes. Median age of recipients was 46 years (range 0.3-73.8 years). HCoV episodes were diagnosed at a median of 222 days after transplantation. The most common HCoV subtype was OC43 (n=170, 38%). LRTD involvement occurred in 121 episodes (27%). HCoV infection frequently required hospitalization (18%), oxygen administration (13%) and intensive care unit (ICU) admission (3%). Three-month overall mortality after HCoV detection was 7% in the whole cohort and 16% in those with LRTD. We identified 3 conditions associated with higher mortality in recipients with LRTD: absolute lymphocyte count <0.1 x10 9/mL [hazard ratio (HR), 10.8], corticosteroid (HR 4.68) and ICU admission (HR 8.22) (p<0.01).CONCLUSIONS: Seasonal HCoV after allo-HCT may involve the LRTD in many instances, leading to a significant morbidity.",
author = "{Infectious Diseases Working Party of the European Society for Blood and Marrow Transplantation and Infectious Complications Subcommittee of the Spanish Hematopoietic Stem Cell Transplantation and Cell Therapy Group (GETH)} and Pi{\~n}ana, {Jose Luis} and Ali{\'e}nor Xhaard and Gloria Tridello and Jakob Passweg and Anne Kozijn and Nicola Polverelli and Inmaculada Heras and Ariadna Perez and Jaime Sanz and Dagmar Berghuis and Lourdes V{\'a}zquez and Mar{\'i}a Su{\'a}rez-Lled{\'o} and Maija It{\"a}la-Remes and Tulay Ozcelik and {Iturrate Basar{\'a}n}, Isabel and Musa Karakukcu and {Al Zahrani}, Mohsen and Goda Choi and {Cuesta Casas}, {Mari{\'a}n Angeles} and {Batlle Massana}, Montserrat and Amato Viviana and Nicole Blijlevens and Arnold Ganser and Baris Kuskonmaz and H{\'e}l{\`e}ne Labussi{\`e}re-Wallet and Shaw, {Peter J} and {Arzu Yegin}, Zeynep and Marta Gonz{\'a}lez-Vicent and Vanderson Rocha and Alina Ferster and Nina Knelange and David Navarro and Malgorzata Mikulska and {de la Camara}, Rafael and Jan Styczynski",
note = "{\textcopyright} The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.",
year = "2020",
month = aug,
day = "29",
doi = "10.1093/infdis/jiaa553",
language = "English",
journal = "The Journal of Infectious Diseases",
issn = "1537-6613",
publisher = "Oxford University Press",

}

RIS

TY - JOUR

T1 - Seasonal human coronaviruses respiratory tract infection in recipients of allogeneic hematopoietic stem cell transplantation

AU - Infectious Diseases Working Party of the European Society for Blood and Marrow Transplantation and Infectious Complications Subcommittee of the Spanish Hematopoietic Stem Cell Transplantation and Cell Therapy Group (GETH)

AU - Piñana, Jose Luis

AU - Xhaard, Aliénor

AU - Tridello, Gloria

AU - Passweg, Jakob

AU - Kozijn, Anne

AU - Polverelli, Nicola

AU - Heras, Inmaculada

AU - Perez, Ariadna

AU - Sanz, Jaime

AU - Berghuis, Dagmar

AU - Vázquez, Lourdes

AU - Suárez-Lledó, María

AU - Itäla-Remes, Maija

AU - Ozcelik, Tulay

AU - Iturrate Basarán, Isabel

AU - Karakukcu, Musa

AU - Al Zahrani, Mohsen

AU - Choi, Goda

AU - Cuesta Casas, Marián Angeles

AU - Batlle Massana, Montserrat

AU - Viviana, Amato

AU - Blijlevens, Nicole

AU - Ganser, Arnold

AU - Kuskonmaz, Baris

AU - Labussière-Wallet, Hélène

AU - Shaw, Peter J

AU - Arzu Yegin, Zeynep

AU - González-Vicent, Marta

AU - Rocha, Vanderson

AU - Ferster, Alina

AU - Knelange, Nina

AU - Navarro, David

AU - Mikulska, Malgorzata

AU - de la Camara, Rafael

AU - Styczynski, Jan

N1 - © The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

PY - 2020/8/29

Y1 - 2020/8/29

N2 - BACKGROUND: Little is known about characteristics of seasonal human coronavirus (HCoV) (NL63, 229E, OC43 and HKU1) after allogeneic stem cell transplantation (allo-HCT).PATIENTS AND METHODS: this is a collaborative Spanish and European bone marrow transplantation groups retrospective multicentre study, which included allo-HCT recipients (adults and children) with upper and/or lower respiratory tract disease (U/LRTD) caused by seasonal HCoV diagnosed through multiplex PCR assays from January 2012 to January 2019.RESULTS: We included 402 allo-HCT recipients who developed 449 HCoV U/LRTD episodes. Median age of recipients was 46 years (range 0.3-73.8 years). HCoV episodes were diagnosed at a median of 222 days after transplantation. The most common HCoV subtype was OC43 (n=170, 38%). LRTD involvement occurred in 121 episodes (27%). HCoV infection frequently required hospitalization (18%), oxygen administration (13%) and intensive care unit (ICU) admission (3%). Three-month overall mortality after HCoV detection was 7% in the whole cohort and 16% in those with LRTD. We identified 3 conditions associated with higher mortality in recipients with LRTD: absolute lymphocyte count <0.1 x10 9/mL [hazard ratio (HR), 10.8], corticosteroid (HR 4.68) and ICU admission (HR 8.22) (p<0.01).CONCLUSIONS: Seasonal HCoV after allo-HCT may involve the LRTD in many instances, leading to a significant morbidity.

AB - BACKGROUND: Little is known about characteristics of seasonal human coronavirus (HCoV) (NL63, 229E, OC43 and HKU1) after allogeneic stem cell transplantation (allo-HCT).PATIENTS AND METHODS: this is a collaborative Spanish and European bone marrow transplantation groups retrospective multicentre study, which included allo-HCT recipients (adults and children) with upper and/or lower respiratory tract disease (U/LRTD) caused by seasonal HCoV diagnosed through multiplex PCR assays from January 2012 to January 2019.RESULTS: We included 402 allo-HCT recipients who developed 449 HCoV U/LRTD episodes. Median age of recipients was 46 years (range 0.3-73.8 years). HCoV episodes were diagnosed at a median of 222 days after transplantation. The most common HCoV subtype was OC43 (n=170, 38%). LRTD involvement occurred in 121 episodes (27%). HCoV infection frequently required hospitalization (18%), oxygen administration (13%) and intensive care unit (ICU) admission (3%). Three-month overall mortality after HCoV detection was 7% in the whole cohort and 16% in those with LRTD. We identified 3 conditions associated with higher mortality in recipients with LRTD: absolute lymphocyte count <0.1 x10 9/mL [hazard ratio (HR), 10.8], corticosteroid (HR 4.68) and ICU admission (HR 8.22) (p<0.01).CONCLUSIONS: Seasonal HCoV after allo-HCT may involve the LRTD in many instances, leading to a significant morbidity.

U2 - 10.1093/infdis/jiaa553

DO - 10.1093/infdis/jiaa553

M3 - Article

C2 - 32860509

JO - The Journal of Infectious Diseases

JF - The Journal of Infectious Diseases

SN - 1537-6613

ER -

ID: 134205230