Seasonal human coronaviruses respiratory tract infection in recipients of allogeneic hematopoietic stem cell transplantationInfectious Diseases Working Party of the European Society for Blood and Marrow Transplantation and Infectious Complications Subcommittee of the Spanish Hematopoietic Stem Cell Transplantation and Cell Therapy Group (GETH), Piñana, J. L., Xhaard, A., Tridello, G., Passweg, J., Kozijn, A., Polverelli, N., Heras, I., Perez, A., Sanz, J., Berghuis, D., Vázquez, L., Suárez-Lledó, M., Itäla-Remes, M., Ozcelik, T., Iturrate Basarán, I., Karakukcu, M., Al Zahrani, M., Choi, G., Cuesta Casas, M. A., Batlle Massana, M., Viviana, A., Blijlevens, N., Ganser, A., Kuskonmaz, B., Labussière-Wallet, H., Shaw, P. J., Arzu Yegin, Z., González-Vicent, M., Rocha, V., Ferster, A., Knelange, N., Navarro, D., Mikulska, M., de la Camara, R. & Styczynski, J., 29-Aug-2020, In : The Journal of Infectious Diseases.
Research output: Contribution to journal › Article › Academic › peer-review
BACKGROUND: Little is known about characteristics of seasonal human coronavirus (HCoV) (NL63, 229E, OC43 and HKU1) after allogeneic stem cell transplantation (allo-HCT).
PATIENTS AND METHODS: this is a collaborative Spanish and European bone marrow transplantation groups retrospective multicentre study, which included allo-HCT recipients (adults and children) with upper and/or lower respiratory tract disease (U/LRTD) caused by seasonal HCoV diagnosed through multiplex PCR assays from January 2012 to January 2019.
RESULTS: We included 402 allo-HCT recipients who developed 449 HCoV U/LRTD episodes. Median age of recipients was 46 years (range 0.3-73.8 years). HCoV episodes were diagnosed at a median of 222 days after transplantation. The most common HCoV subtype was OC43 (n=170, 38%). LRTD involvement occurred in 121 episodes (27%). HCoV infection frequently required hospitalization (18%), oxygen administration (13%) and intensive care unit (ICU) admission (3%). Three-month overall mortality after HCoV detection was 7% in the whole cohort and 16% in those with LRTD. We identified 3 conditions associated with higher mortality in recipients with LRTD: absolute lymphocyte count <0.1 x10 9/mL [hazard ratio (HR), 10.8], corticosteroid (HR 4.68) and ICU admission (HR 8.22) (p<0.01).
CONCLUSIONS: Seasonal HCoV after allo-HCT may involve the LRTD in many instances, leading to a significant morbidity.
|Journal||The Journal of Infectious Diseases|
|Publication status||E-pub ahead of print - 29-Aug-2020|