Publication

Scrotal Irradiation in Primary Testicular Lymphoma: Review of the Literature and In Silico Planning Comparative Study

Brouwer, C. L., Wiesendanger, E. M., van der Hulst, P. C., van Imhoff, G. W., Langendijk, J. A. & Beijert, M., 1-Feb-2013, In : International Journal of Radiation Oncology Biology Physics. 85, 2, p. 298-308 11 p.

Research output: Contribution to journalReview articleAcademicpeer-review

APA

Brouwer, C. L., Wiesendanger, E. M., van der Hulst, P. C., van Imhoff, G. W., Langendijk, J. A., & Beijert, M. (2013). Scrotal Irradiation in Primary Testicular Lymphoma: Review of the Literature and In Silico Planning Comparative Study. International Journal of Radiation Oncology Biology Physics, 85(2), 298-308. https://doi.org/10.1016/j.ijrobp.2012.06.019

Author

Brouwer, Charlotte L. ; Wiesendanger, Esther M. ; van der Hulst, Peter C. ; van Imhoff, Gustaaf W. ; Langendijk, Johannes A. ; Beijert, Max. / Scrotal Irradiation in Primary Testicular Lymphoma : Review of the Literature and In Silico Planning Comparative Study. In: International Journal of Radiation Oncology Biology Physics. 2013 ; Vol. 85, No. 2. pp. 298-308.

Harvard

Brouwer, CL, Wiesendanger, EM, van der Hulst, PC, van Imhoff, GW, Langendijk, JA & Beijert, M 2013, 'Scrotal Irradiation in Primary Testicular Lymphoma: Review of the Literature and In Silico Planning Comparative Study', International Journal of Radiation Oncology Biology Physics, vol. 85, no. 2, pp. 298-308. https://doi.org/10.1016/j.ijrobp.2012.06.019

Standard

Scrotal Irradiation in Primary Testicular Lymphoma : Review of the Literature and In Silico Planning Comparative Study. / Brouwer, Charlotte L.; Wiesendanger, Esther M.; van der Hulst, Peter C.; van Imhoff, Gustaaf W.; Langendijk, Johannes A.; Beijert, Max.

In: International Journal of Radiation Oncology Biology Physics, Vol. 85, No. 2, 01.02.2013, p. 298-308.

Research output: Contribution to journalReview articleAcademicpeer-review

Vancouver

Brouwer CL, Wiesendanger EM, van der Hulst PC, van Imhoff GW, Langendijk JA, Beijert M. Scrotal Irradiation in Primary Testicular Lymphoma: Review of the Literature and In Silico Planning Comparative Study. International Journal of Radiation Oncology Biology Physics. 2013 Feb 1;85(2):298-308. https://doi.org/10.1016/j.ijrobp.2012.06.019


BibTeX

@article{9dc34becf51b408c8c99585f6b2873f7,
title = "Scrotal Irradiation in Primary Testicular Lymphoma: Review of the Literature and In Silico Planning Comparative Study",
abstract = "We examined adjuvant irradiation of the scrotum in primary testicular lymphoma (PTL) by means of a literature review in MEDLINE, a telephone survey among Dutch institutes, and an in silico planning comparative study on scrotal irradiation in PTL.We did not find any uniform adjuvant irradiation technique assuring a safe planning target volume (PTV) coverage in published reports, and the definition of the clinical target volume is unclear. Histopathologic studies of PTL show a high invasion rate of the tunica albuginea, the epididymis, and the spermatic cord. In retrospective studies, a prescribed dose of at least 30 Gy involving the scrotum is associated with best survival. The majority of Dutch institutes irradiate the whole scrotum without using a planning computed tomography scan, with a single electron beam and a total dose of 30 Gy. The in silico planning comparative study showed that all evaluated approaches met a D-95{\%} scrotal dose of at least 85{\%} of the prescription dose, without exceeding the dose limits of critical organs. Photon irradiation with 2 oblique beams using wedges resulted in the best PTV coverage, with a mean value of 95{\%} of the prescribed dose, with lowest maximum dose.Adjuvant photon or electron irradiation of the whole scrotum including the contralateral testicle with a minimum dose of 30 Gy is recommended in PTL. Computed tomography-based radiation therapy treatment planning with proper patient positioning and position verification guarantees optimal dose coverage. (C) 2013 Elsevier Inc.",
keywords = "NON-HODGKINS-LYMPHOMA, DOXORUBICIN-BASED THERAPY, LARGE-CELL LYMPHOMA, MALIGNANT-LYMPHOMA, EXTRANODAL LYMPHOMA, PROGNOSTIC-FACTORS, GONADAL-FUNCTION, GROUP EXPERIENCE, NORMAL TISSUE, TESTIS",
author = "Brouwer, {Charlotte L.} and Wiesendanger, {Esther M.} and {van der Hulst}, {Peter C.} and {van Imhoff}, {Gustaaf W.} and Langendijk, {Johannes A.} and Max Beijert",
year = "2013",
month = "2",
day = "1",
doi = "10.1016/j.ijrobp.2012.06.019",
language = "English",
volume = "85",
pages = "298--308",
journal = "International Journal of Radiation Oncology Biology Physics",
issn = "0360-3016",
publisher = "ELSEVIER SCIENCE INC",
number = "2",

}

RIS

TY - JOUR

T1 - Scrotal Irradiation in Primary Testicular Lymphoma

T2 - Review of the Literature and In Silico Planning Comparative Study

AU - Brouwer, Charlotte L.

AU - Wiesendanger, Esther M.

AU - van der Hulst, Peter C.

AU - van Imhoff, Gustaaf W.

AU - Langendijk, Johannes A.

AU - Beijert, Max

PY - 2013/2/1

Y1 - 2013/2/1

N2 - We examined adjuvant irradiation of the scrotum in primary testicular lymphoma (PTL) by means of a literature review in MEDLINE, a telephone survey among Dutch institutes, and an in silico planning comparative study on scrotal irradiation in PTL.We did not find any uniform adjuvant irradiation technique assuring a safe planning target volume (PTV) coverage in published reports, and the definition of the clinical target volume is unclear. Histopathologic studies of PTL show a high invasion rate of the tunica albuginea, the epididymis, and the spermatic cord. In retrospective studies, a prescribed dose of at least 30 Gy involving the scrotum is associated with best survival. The majority of Dutch institutes irradiate the whole scrotum without using a planning computed tomography scan, with a single electron beam and a total dose of 30 Gy. The in silico planning comparative study showed that all evaluated approaches met a D-95% scrotal dose of at least 85% of the prescription dose, without exceeding the dose limits of critical organs. Photon irradiation with 2 oblique beams using wedges resulted in the best PTV coverage, with a mean value of 95% of the prescribed dose, with lowest maximum dose.Adjuvant photon or electron irradiation of the whole scrotum including the contralateral testicle with a minimum dose of 30 Gy is recommended in PTL. Computed tomography-based radiation therapy treatment planning with proper patient positioning and position verification guarantees optimal dose coverage. (C) 2013 Elsevier Inc.

AB - We examined adjuvant irradiation of the scrotum in primary testicular lymphoma (PTL) by means of a literature review in MEDLINE, a telephone survey among Dutch institutes, and an in silico planning comparative study on scrotal irradiation in PTL.We did not find any uniform adjuvant irradiation technique assuring a safe planning target volume (PTV) coverage in published reports, and the definition of the clinical target volume is unclear. Histopathologic studies of PTL show a high invasion rate of the tunica albuginea, the epididymis, and the spermatic cord. In retrospective studies, a prescribed dose of at least 30 Gy involving the scrotum is associated with best survival. The majority of Dutch institutes irradiate the whole scrotum without using a planning computed tomography scan, with a single electron beam and a total dose of 30 Gy. The in silico planning comparative study showed that all evaluated approaches met a D-95% scrotal dose of at least 85% of the prescription dose, without exceeding the dose limits of critical organs. Photon irradiation with 2 oblique beams using wedges resulted in the best PTV coverage, with a mean value of 95% of the prescribed dose, with lowest maximum dose.Adjuvant photon or electron irradiation of the whole scrotum including the contralateral testicle with a minimum dose of 30 Gy is recommended in PTL. Computed tomography-based radiation therapy treatment planning with proper patient positioning and position verification guarantees optimal dose coverage. (C) 2013 Elsevier Inc.

KW - NON-HODGKINS-LYMPHOMA

KW - DOXORUBICIN-BASED THERAPY

KW - LARGE-CELL LYMPHOMA

KW - MALIGNANT-LYMPHOMA

KW - EXTRANODAL LYMPHOMA

KW - PROGNOSTIC-FACTORS

KW - GONADAL-FUNCTION

KW - GROUP EXPERIENCE

KW - NORMAL TISSUE

KW - TESTIS

U2 - 10.1016/j.ijrobp.2012.06.019

DO - 10.1016/j.ijrobp.2012.06.019

M3 - Review article

VL - 85

SP - 298

EP - 308

JO - International Journal of Radiation Oncology Biology Physics

JF - International Journal of Radiation Oncology Biology Physics

SN - 0360-3016

IS - 2

ER -

ID: 5766044