Scaffold hopping via ANCHOR.QUERY: beta-lactams as potent p53-MDM2 antagonistsShaabani, S., Neochoritis, C. G., Twarda-Clapa, A., Musielak, B., Holak, T. A. & Domling, A., May-2017, In : MedChemCommun. 8, 5, p. 1046-1052 7 p.
Research output: Contribution to journal › Article › Academic › peer-review
Using the pharmacophore-based virtual screening platform ANCHOR.QUERY, we morphed our recently described Ugi-4CR scaffold towards a beta-lactam scaffold with potent p53-MDM2 antagonizing activities. 2D-HSQC and FP measurements confirm potent MDM2 binding. Molecular modeling studies were used to understand the observed SAR in the beta-lactam series.
|Number of pages||7|
|Publication status||Published - May-2017|
- PROTEIN-PROTEIN INTERACTIONS, MULTICOMPONENT REACTIONS, MDM2-P53 INTERACTION, STEREOSELECTIVE-SYNTHESIS, INHIBITORS, CHEMISTRY, DESIGN, P53, DISCOVERY, AFFINITY