Saved by the Matrix: UPR Independent Survival under ER Stress

Koopman, M., Hetz, C. & Nollen, E. A. A., 27-Nov-2019, In : Cell. 179, 6, p. 1246-1248 3 p.

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Cells are protected from endoplasmic reticulum stress through the unfolded protein response (UPR). In this issue of Cell, Schinzel, Higuchi-Sanabria, Shalem et al., identify a mechanism that helps cells cope with ER stress but is independent of canonical UPR activation, instead involving the extracellular matrix hyaluronidase, TMEM2, as a signaling mediator.

Original languageEnglish
Pages (from-to)1246-1248
Number of pages3
Issue number6
Publication statusPublished - 27-Nov-2019

ID: 107804733