SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genesHCA Lung Biological, Sungnak, W., Huang, N., Becavin, C., Berg, M., Queen, R., Litvinukova, M., Talavera-Lopez, C., Maatz, H., Reichart, D., Sampaziotis, F., Worlock, K. B., Yoshida, M. & Barnes, J. L., 23-Apr-2020, In : Nature Medicine. 14 p.
Research output: Contribution to journal › Article › Academic › peer-review
We investigated SARS-CoV-2 potential tropism by surveying expression of viral entry-associated genes in single-cell RNA-sequencing data from multiple tissues from healthy human donors. We co-detected these transcripts in specific respiratory, corneal and intestinal epithelial cells, potentially explaining the high efficiency of SARS-CoV-2 transmission. These genes are co-expressed in nasal epithelial cells with genes involved in innate immunity, highlighting the cells' potential role in initial viral infection, spread and clearance. The study offers a useful resource for further lines of inquiry with valuable clinical samples from COVID-19 patients and we provide our data in a comprehensive, open and user-friendly fashion at www.covid19cellatlas.org.
|Number of pages||14|
|Publication status||Published - 23-Apr-2020|
- FUNCTIONAL RECEPTOR, CORONAVIRUS, PROTEIN, WUHAN