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SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes

HCA Lung Biological, Sungnak, W., Huang, N., Becavin, C., Berg, M., Queen, R., Litvinukova, M., Talavera-Lopez, C., Maatz, H., Reichart, D., Sampaziotis, F., Worlock, K. B., Yoshida, M. & Barnes, J. L., 23-Apr-2020, In : Nature Medicine. 14 p.

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  • SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes

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DOI

  • HCA Lung Biological
  • Waradon Sungnak
  • Ni Huang
  • Christophe Becavin
  • Marijn Berg
  • Rachel Queen
  • Monika Litvinukova
  • Carlos Talavera-Lopez
  • Henrike Maatz
  • Daniel Reichart
  • Fotios Sampaziotis
  • Kaylee B. Worlock
  • Masahiro Yoshida
  • Josephine L. Barnes

We investigated SARS-CoV-2 potential tropism by surveying expression of viral entry-associated genes in single-cell RNA-sequencing data from multiple tissues from healthy human donors. We co-detected these transcripts in specific respiratory, corneal and intestinal epithelial cells, potentially explaining the high efficiency of SARS-CoV-2 transmission. These genes are co-expressed in nasal epithelial cells with genes involved in innate immunity, highlighting the cells' potential role in initial viral infection, spread and clearance. The study offers a useful resource for further lines of inquiry with valuable clinical samples from COVID-19 patients and we provide our data in a comprehensive, open and user-friendly fashion at www.covid19cellatlas.org.

Original languageEnglish
Number of pages14
JournalNature Medicine
Publication statusPublished - 23-Apr-2020

    Keywords

  • FUNCTIONAL RECEPTOR, CORONAVIRUS, PROTEIN, WUHAN

ID: 123648300