Publication

Sarcopenic obesity predicts nonremission of late-life depression

Kokkeler, K. J. E., van den Berg, K. S., Comijs, H. C., Voshaar, R. C. O. & Marijnissen, R. M., Aug-2019, In : International Journal of Geriatric Psychiatry. 34, 8, p. 1226-1234 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Kokkeler, K. J. E., van den Berg, K. S., Comijs, H. C., Voshaar, R. C. O., & Marijnissen, R. M. (2019). Sarcopenic obesity predicts nonremission of late-life depression. International Journal of Geriatric Psychiatry, 34(8), 1226-1234. https://doi.org/10.1002/gps.5121

Author

Kokkeler, Kitty J. E. ; van den Berg, Karen S. ; Comijs, Hannie C. ; Voshaar, Richard C. Oude ; Marijnissen, Radboud M. / Sarcopenic obesity predicts nonremission of late-life depression. In: International Journal of Geriatric Psychiatry. 2019 ; Vol. 34, No. 8. pp. 1226-1234.

Harvard

Kokkeler, KJE, van den Berg, KS, Comijs, HC, Voshaar, RCO & Marijnissen, RM 2019, 'Sarcopenic obesity predicts nonremission of late-life depression', International Journal of Geriatric Psychiatry, vol. 34, no. 8, pp. 1226-1234. https://doi.org/10.1002/gps.5121

Standard

Sarcopenic obesity predicts nonremission of late-life depression. / Kokkeler, Kitty J. E.; van den Berg, Karen S.; Comijs, Hannie C.; Voshaar, Richard C. Oude; Marijnissen, Radboud M.

In: International Journal of Geriatric Psychiatry, Vol. 34, No. 8, 08.2019, p. 1226-1234.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Kokkeler KJE, van den Berg KS, Comijs HC, Voshaar RCO, Marijnissen RM. Sarcopenic obesity predicts nonremission of late-life depression. International Journal of Geriatric Psychiatry. 2019 Aug;34(8):1226-1234. https://doi.org/10.1002/gps.5121


BibTeX

@article{f0ffb2073c6b45a5865100d90ed1090b,
title = "Sarcopenic obesity predicts nonremission of late-life depression",
abstract = "Background/objectives Aging-related physiological changes like metabolic dysregulation and physical frailty are associated with depression and worsen its prognosis. Since central obesity is a key component of the metabolic syndrome and sarcopenia of physical frailty, we examined the association of sarcopenic obesity with depression cross-sectional and over time. Methods Cohort study of depressed patients and a nondepressed comparison group. Setting Primary and secondary mental health care. Participants Three hundred seventy-eight older (>= 60 y) depressed patients of which 285 were followed up at 2 years and 132 nondepressed persons participating in the Netherlands Study of Depression in Older (NESDO) persons. Measurements Sarcopenic obesity was based on predefined cutoffs for both maximum handgrip strength (assessed with a dynamometer) and waist circumference (dichotomous) as well as the product term of handgrip strength by waist circumference (dimensional). Depressive disorder according to DSM-IV-TR criteria was assessed with fully structured psychiatric interview at baseline and 2-year follow-up. Results Sarcopenic obesity was more prevalent among depressed patients compared with nondepressed participants (18.9{\%} versus 10.7{\%}, P = 0.030). Neither the dichotomous nor dimensional operationalization of sarcopenic obesity was associated with baseline depressive disorder when adjusted for covariates. Nonetheless, among depressed patients, logistic regression showed that the interaction of handgrip strength by waist circumference was associated with remitted depression at 2-year follow-up (P = 0.044). Only among patients with a low handgrip strength, a higher waist circumference predicted nonremission. Conclusion Among depressed patients, sarcopenic obesity predicts nonremission of depression. Therefore, combined exercise and nutritional interventions might be effective for depressed patients with sarcopenic obesity.",
keywords = "abdominal obesity, depression, elderly, sarcopenia, sarcopenic obesity, METABOLIC SYNDROME, OLDER-ADULTS, WAIST CIRCUMFERENCE, NEUROTROPHIC FACTOR, BODY-COMPOSITION, NATIONAL-HEALTH, ASSOCIATION, SYMPTOMS, FRAILTY, PREVALENCE",
author = "Kokkeler, {Kitty J. E.} and {van den Berg}, {Karen S.} and Comijs, {Hannie C.} and Voshaar, {Richard C. Oude} and Marijnissen, {Radboud M.}",
year = "2019",
month = "8",
doi = "10.1002/gps.5121",
language = "English",
volume = "34",
pages = "1226--1234",
journal = "International Journal of Geriatric Psychiatry",
issn = "0885-6230",
publisher = "WILEY",
number = "8",

}

RIS

TY - JOUR

T1 - Sarcopenic obesity predicts nonremission of late-life depression

AU - Kokkeler, Kitty J. E.

AU - van den Berg, Karen S.

AU - Comijs, Hannie C.

AU - Voshaar, Richard C. Oude

AU - Marijnissen, Radboud M.

PY - 2019/8

Y1 - 2019/8

N2 - Background/objectives Aging-related physiological changes like metabolic dysregulation and physical frailty are associated with depression and worsen its prognosis. Since central obesity is a key component of the metabolic syndrome and sarcopenia of physical frailty, we examined the association of sarcopenic obesity with depression cross-sectional and over time. Methods Cohort study of depressed patients and a nondepressed comparison group. Setting Primary and secondary mental health care. Participants Three hundred seventy-eight older (>= 60 y) depressed patients of which 285 were followed up at 2 years and 132 nondepressed persons participating in the Netherlands Study of Depression in Older (NESDO) persons. Measurements Sarcopenic obesity was based on predefined cutoffs for both maximum handgrip strength (assessed with a dynamometer) and waist circumference (dichotomous) as well as the product term of handgrip strength by waist circumference (dimensional). Depressive disorder according to DSM-IV-TR criteria was assessed with fully structured psychiatric interview at baseline and 2-year follow-up. Results Sarcopenic obesity was more prevalent among depressed patients compared with nondepressed participants (18.9% versus 10.7%, P = 0.030). Neither the dichotomous nor dimensional operationalization of sarcopenic obesity was associated with baseline depressive disorder when adjusted for covariates. Nonetheless, among depressed patients, logistic regression showed that the interaction of handgrip strength by waist circumference was associated with remitted depression at 2-year follow-up (P = 0.044). Only among patients with a low handgrip strength, a higher waist circumference predicted nonremission. Conclusion Among depressed patients, sarcopenic obesity predicts nonremission of depression. Therefore, combined exercise and nutritional interventions might be effective for depressed patients with sarcopenic obesity.

AB - Background/objectives Aging-related physiological changes like metabolic dysregulation and physical frailty are associated with depression and worsen its prognosis. Since central obesity is a key component of the metabolic syndrome and sarcopenia of physical frailty, we examined the association of sarcopenic obesity with depression cross-sectional and over time. Methods Cohort study of depressed patients and a nondepressed comparison group. Setting Primary and secondary mental health care. Participants Three hundred seventy-eight older (>= 60 y) depressed patients of which 285 were followed up at 2 years and 132 nondepressed persons participating in the Netherlands Study of Depression in Older (NESDO) persons. Measurements Sarcopenic obesity was based on predefined cutoffs for both maximum handgrip strength (assessed with a dynamometer) and waist circumference (dichotomous) as well as the product term of handgrip strength by waist circumference (dimensional). Depressive disorder according to DSM-IV-TR criteria was assessed with fully structured psychiatric interview at baseline and 2-year follow-up. Results Sarcopenic obesity was more prevalent among depressed patients compared with nondepressed participants (18.9% versus 10.7%, P = 0.030). Neither the dichotomous nor dimensional operationalization of sarcopenic obesity was associated with baseline depressive disorder when adjusted for covariates. Nonetheless, among depressed patients, logistic regression showed that the interaction of handgrip strength by waist circumference was associated with remitted depression at 2-year follow-up (P = 0.044). Only among patients with a low handgrip strength, a higher waist circumference predicted nonremission. Conclusion Among depressed patients, sarcopenic obesity predicts nonremission of depression. Therefore, combined exercise and nutritional interventions might be effective for depressed patients with sarcopenic obesity.

KW - abdominal obesity

KW - depression

KW - elderly

KW - sarcopenia

KW - sarcopenic obesity

KW - METABOLIC SYNDROME

KW - OLDER-ADULTS

KW - WAIST CIRCUMFERENCE

KW - NEUROTROPHIC FACTOR

KW - BODY-COMPOSITION

KW - NATIONAL-HEALTH

KW - ASSOCIATION

KW - SYMPTOMS

KW - FRAILTY

KW - PREVALENCE

U2 - 10.1002/gps.5121

DO - 10.1002/gps.5121

M3 - Article

VL - 34

SP - 1226

EP - 1234

JO - International Journal of Geriatric Psychiatry

JF - International Journal of Geriatric Psychiatry

SN - 0885-6230

IS - 8

ER -

ID: 97352562