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Safety and Outcome of Endovascular Treatment for Minor Ischemic Stroke: Results From the Multicenter Clinical Registry of Endovascular Treatment of Acute Ischemic Stroke in the Netherlands

MR CLEAN Registry Investigators, Goldhoorn, R. B., Mulder, M. J. H. L., Jansen, I. G. H., van Zwam, W. H., Staals, J., van der Lugt, A., Dippel, D. W. J., Lingsma, H. F., Vos, J. A., Boiten, J., van den Wijngaard, I. R., Majoie, C. B. L. M., Roos, Y. B. W. E. M., van Oostenbrugge, R. J., Vos, J-A., Goldhoorn, R-J. B., Schonewille, W. J., Coutinho, J. M., Wermer, M. J. H., van Walderveen, M. A. A., Hofmeijer, J., Martens, J. M., Nijeholt, G. J. L. A., Roozenbeek, B., Emmer, B., de Bruijn, S. F., van Dijk, L. C., van der Worp, H. B., Lo, R. H., van Dijk, E. J., Boogaarts, H. D., de Kort, P. L. M., Peluso, J. J. P., van den Berg, J. S. P., van Hasselt, B. A. A. M., Aerden, L. A. M., Dallinga, R. J., Uyttenboogaart, M., Eshghi, O., Schreuder, T. H. C. M. L., Heijboer, R. J. J., Keizer, K., Yo, L. S. F., den Hertog, H. M., Sturm, E. J. C., Sprengers, M. E. S., Jenniskens, S. F. M., van den Berg, R., Boers, A. M. M. & Groot, P. F. C., Mar-2019, In : Journal of Stroke & Cerebrovascular Diseases. 28, 3, p. 542-549 8 p.

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  • Safety and Outcome of Endovascular Treatment for Minor Ischemic Stroke

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DOI

  • MR CLEAN Registry Investigators
  • R. B. Goldhoorn
  • Maxim J. H. L. Mulder
  • Ivo G. H. Jansen
  • Wim H. van Zwam
  • Julie Staals
  • Aad van der Lugt
  • Diederik W. J. Dippel
  • Hester F. Lingsma
  • Jan Albert Vos
  • Jelis Boiten
  • Ido R. van den Wijngaard
  • Charles B. L. M. Majoie
  • Yvo B. W. E. M. Roos
  • Robert J. van Oostenbrugge
  • Jan-Albert Vos
  • Robert-Jan B. Goldhoorn
  • Wouter J. Schonewille
  • Jonathan M. Coutinho
  • Marieke J. H. Wermer
  • Marianne A. A. van Walderveen
  • Jeannette Hofmeijer
  • Jasper M. Martens
  • Geert J. Lycklama A. Nijeholt
  • Bob Roozenbeek
  • Bart Emmer
  • Sebastiaan F. de Bruijn
  • Lukas C. van Dijk
  • H. Bart van der Worp
  • Rob H. Lo
  • Ewoud J. van Dijk
  • Hieronymus D. Boogaarts
  • Paul L. M. de Kort
  • Jo J. P. Peluso
  • Jan S. P. van den Berg
  • Boudewijn A. A. M. van Hasselt
  • Leo A. M. Aerden
  • Rene J. Dallinga
  • Maarten Uyttenboogaart
  • Omid Eshghi
  • Tobien H. C. M. L. Schreuder
  • Roel J. J. Heijboer
  • Koos Keizer
  • Lonneke S. F. Yo
  • Heleen M. den Hertog
  • Emiel J. C. Sturm
  • Marieke E. S. Sprengers
  • Sjoerd F. M. Jenniskens
  • Rene van den Berg
  • Anna M. M. Boers
  • P. F. C. Groot

Goal: Insufficient data is available about safety and efficacy of endovascular treatment (EVT) in patients with minor stroke symptoms because these patients were excluded from most randomized trials. We aimed to compare characteristics, functional outcome, and complications in patients with minor ischemic stroke National Institutes of Health Stroke Scale score = 6) due to intracranial proximal artery occlusion of the anterior circulation who underwent EVT. Materials and Methods: We report patients with an anterior circulation occlusion who were included between March 2014 and June 2016 in the multicenter randomized clinical trial of EVT of acute ischemic stroke in the Netherlands Registry, a prospective, multicenter, observational study for stroke centers that perform EVT in the Netherlands. Minor ischemic stroke was defined as baseline NIHSS score of 5 or less. Primary outcome is the modified Rankin Scale (mRS) score at 90 days. Secondary outcomes include symptomatic intracranial hemorrhage (sICH) and mortality. Findings: Seventy-one (5.5%) patients had a NIHSS score of 5 or less. Functional independence (mRS 0-2 at 90 days) was reached in 75% of these patients, compared to 40% of patients with NIHSS score of 6 or more. sICH occurred in 4% of patients, of which 1% occurred peri-interventionally. Death occurred in 6% of patients. Conclusions: Patients with minor ischemic stroke with an intracranial proximal arterial occlusion of the anterior circulation who underwent EVT have a high chance of favorable outcome and appear to have low occurrence of treatment-related sICH. Therefore, our results encourage the use of EVT for minor ischemic stroke in the absence of effect estimates from controlled studies.

Original languageEnglish
Pages (from-to)542-549
Number of pages8
JournalJournal of Stroke & Cerebrovascular Diseases
Volume28
Issue number3
Publication statusPublished - Mar-2019

    Keywords

  • Ischemic stroke, endovascular treatment, minor symptoms, large vessel oclusion, LARGE VESSEL OCCLUSION, INTRAARTERIAL TREATMENT, ANTERIOR CIRCULATION, SCALE SCORE, THERAPY, MILD, THROMBECTOMY, ANGIOGRAPHY, TRIAL

ID: 77238952