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Safety and Efficacy of Beta-Blockers in the Treatment of Stable Angina Pectoris

De Muinck, E. D. & Lie, K. I., 1990, In : Journal of Cardiovascular Pharmacology. 16, p. S123-S128 6 p.

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  • Safety and Efficacy of Beta-Blockers in the Treatment of Stable Angina Pectoris

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  • E. D. De Muinck
  • K. I. Lie

In stable exercise-induced angina pectoris, beta-blockers exert their beneficial effects mainly through a reduction in heart rate, blood pressure, and contractility. Additional beneficial effects are an improvement in myocardial oxygen supply through a redistribution of coronary flow, a lengthening of diastole, a facilitation of aerobic metabolism, and a rightward shift of the oxygen-hemoglobin dissociation curve. Cardioselective beta-blockers can be expected to have fewer side effects than the nonselective drugs. Apart from a reduction in anginal attack rate and an improvement in exercise capacity, a reduction in silent ischemia may be desirable when treating patients with stable effort angina. Beta-blockers effectively reduce asymptomatic ischemia. Bisorprolol is a new beta-1-selective beta-blocker with a clear 24-h duration of action regarding symptoms stable exercise-induced angina pectoris. Bisoprolol 10 mg and atenolol 100 mg are equipotent in achieving these effects.

Original languageEnglish
Pages (from-to)S123-S128
Number of pages6
JournalJournal of Cardiovascular Pharmacology
Volume16
Publication statusPublished - 1990
Event3RD INTERNATIONAL SYMP ON BISOPROLOL : THE ROLE OF BETA-BLOCKADE IN MODERN CARDIOVASCULAR THERAPY - , Spain
Duration: 29-Sep-19891-Oct-1989

Event

3RD INTERNATIONAL SYMP ON BISOPROLOL : THE ROLE OF BETA-BLOCKADE IN MODERN CARDIOVASCULAR THERAPY

29/09/198901/10/1989

Spain

Event: Other

    Keywords

  • BETA-BLOCKADE, EFFORT ANGINA, OVERVIEW, INTRINSIC SYMPATHOMIMETIC ACTIVITY, SILENT MYOCARDIAL ISCHEMIA, CORONARY-ARTERY DISEASE, EXERCISE TOLERANCE, HEART-DISEASE, PROPRANOLOL, PINDOLOL, ATENOLOL, BLOCKADE, DRUGS

ID: 6278202