Safety and Efficacy of Beta-Blockers in the Treatment of Stable Angina PectorisDe Muinck, E. D. & Lie, K. I., 1990, In : Journal of Cardiovascular Pharmacology. 16, p. S123-S128 6 p.
Research output: Contribution to journal › Article › Academic › peer-review
In stable exercise-induced angina pectoris, beta-blockers exert their beneficial effects mainly through a reduction in heart rate, blood pressure, and contractility. Additional beneficial effects are an improvement in myocardial oxygen supply through a redistribution of coronary flow, a lengthening of diastole, a facilitation of aerobic metabolism, and a rightward shift of the oxygen-hemoglobin dissociation curve. Cardioselective beta-blockers can be expected to have fewer side effects than the nonselective drugs. Apart from a reduction in anginal attack rate and an improvement in exercise capacity, a reduction in silent ischemia may be desirable when treating patients with stable effort angina. Beta-blockers effectively reduce asymptomatic ischemia. Bisorprolol is a new beta-1-selective beta-blocker with a clear 24-h duration of action regarding symptoms stable exercise-induced angina pectoris. Bisoprolol 10 mg and atenolol 100 mg are equipotent in achieving these effects.
|Number of pages||6|
|Journal||Journal of Cardiovascular Pharmacology|
|Publication status||Published - 1990|
|Event||3RD INTERNATIONAL SYMP ON BISOPROLOL : THE ROLE OF BETA-BLOCKADE IN MODERN CARDIOVASCULAR THERAPY - , Spain|
Duration: 29-Sep-1989 → 1-Oct-1989
3RD INTERNATIONAL SYMP ON BISOPROLOL : THE ROLE OF BETA-BLOCKADE IN MODERN CARDIOVASCULAR THERAPY
29/09/1989 → 01/10/1989Spain
- BETA-BLOCKADE, EFFORT ANGINA, OVERVIEW, INTRINSIC SYMPATHOMIMETIC ACTIVITY, SILENT MYOCARDIAL ISCHEMIA, CORONARY-ARTERY DISEASE, EXERCISE TOLERANCE, HEART-DISEASE, PROPRANOLOL, PINDOLOL, ATENOLOL, BLOCKADE, DRUGS