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Saddle-Shaped Annuloplasty Improves Leaflet Coaptation in Repair for Ischemic Mitral Regurgitation

Bouma, W., Aoki, C., Vergnat, M., Pouch, A. M., Sprinkle, S. R., Gillespie, M. J., Mariani, M. A., Jackson, B. M., Gorman, R. C. & Gorman, J. H., Oct-2015, In : Annals of thoracic surgery. 100, 4, p. 1360-1366 7 p.

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  • Saddle-Shaped Annuloplasty Improves Leaflet Coaptation in Repair for Ischemic

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DOI

  • Wobbe Bouma
  • Chikashi Aoki
  • Mathieu Vergnat
  • Alison M. Pouch
  • Shanna R. Sprinkle
  • Matthew J. Gillespie
  • Massimo A. Mariani
  • Benjamin M. Jackson
  • Robert C. Gorman
  • Joseph H. Gorman

Background. Current repair results for ischemic mitral regurgitation (IMR) with undersized annuloplasty rings are characterized by high IMR recurrence rates. Current annuloplasty rings treat annular dilatation, but they do little to improve (and may actually exacerbate) leaflet tethering. New saddle-shaped annuloplasty rings have been shown to maintain or restore a more physiologic annular and leaflet geometry and function. Using a porcine IMR model, we sought to demonstrate the influence of annuloplasty ring shape on leaflet coaptation.

Methods. Eight weeks after posterolateral infarct, eight pigs with grade 2D or higher IMR were randomized to undergo either a 28-mm flat ring annuloplasty (n=4) or a 28-mm saddle-shaped ring annuloplasty (n=4). Realtime three-dimensional echocardiography and a customized image analysis protocol allowed three-dimensional assessment of leaflet coaptation before and after annuloplasty.

Results. Total leaflet coaptation area was significantly higher after saddle-shaped ring annuloplasty (109.6 +/- 26.9 mm(2)) compared with flat ring annuloplasty (46.2 +/- 7.7 mm(2), p <0.01). After annuloplasty, total coaptation area decreased by 87.5 mm(2) (or 65%) in the flat annuloplasty group (p = 0.01), whereas total coaptation area increased by 22.2 mm(2) (or 25%) in the saddle-shaped annuloplasty group (p = 0.28).

Conclusions. This study shows that the use of undersized saddle-shaped annuloplasty rings in mitral valve repair for IMR improves leaflet coaptation, whereas the use of undersized flat annuloplasty rings worsens leaflet coaptation. Because one of Carpentier's fundamental principles of mitral valve repair (durability) is to create a large surface of coaptation, saddle-shaped annuloplasty may increase repair durability. (C) 2015 by The Society of Thoracic Surgeons

Original languageEnglish
Pages (from-to)1360-1366
Number of pages7
JournalAnnals of thoracic surgery
Volume100
Issue number4
Publication statusPublished - Oct-2015

    Keywords

  • POSTERIOR LEAFLET, MYOCARDIAL-INFARCTION, VALVE, GEOMETRY, REPLACEMENT, CURVATURE, SEVERITY, SURVIVAL, MODEL

ID: 25131381