Saddle-Shaped Annuloplasty Improves Leaflet Coaptation in Repair for Ischemic Mitral RegurgitationBouma, W., Aoki, C., Vergnat, M., Pouch, A. M., Sprinkle, S. R., Gillespie, M. J., Mariani, M. A., Jackson, B. M., Gorman, R. C. & Gorman, J. H., Oct-2015, In : Annals of thoracic surgery. 100, 4, p. 1360-1366 7 p.
Research output: Contribution to journal › Article › Academic › peer-review
Background. Current repair results for ischemic mitral regurgitation (IMR) with undersized annuloplasty rings are characterized by high IMR recurrence rates. Current annuloplasty rings treat annular dilatation, but they do little to improve (and may actually exacerbate) leaflet tethering. New saddle-shaped annuloplasty rings have been shown to maintain or restore a more physiologic annular and leaflet geometry and function. Using a porcine IMR model, we sought to demonstrate the influence of annuloplasty ring shape on leaflet coaptation.
Methods. Eight weeks after posterolateral infarct, eight pigs with grade 2D or higher IMR were randomized to undergo either a 28-mm flat ring annuloplasty (n=4) or a 28-mm saddle-shaped ring annuloplasty (n=4). Realtime three-dimensional echocardiography and a customized image analysis protocol allowed three-dimensional assessment of leaflet coaptation before and after annuloplasty.
Results. Total leaflet coaptation area was significantly higher after saddle-shaped ring annuloplasty (109.6 +/- 26.9 mm(2)) compared with flat ring annuloplasty (46.2 +/- 7.7 mm(2), p <0.01). After annuloplasty, total coaptation area decreased by 87.5 mm(2) (or 65%) in the flat annuloplasty group (p = 0.01), whereas total coaptation area increased by 22.2 mm(2) (or 25%) in the saddle-shaped annuloplasty group (p = 0.28).
Conclusions. This study shows that the use of undersized saddle-shaped annuloplasty rings in mitral valve repair for IMR improves leaflet coaptation, whereas the use of undersized flat annuloplasty rings worsens leaflet coaptation. Because one of Carpentier's fundamental principles of mitral valve repair (durability) is to create a large surface of coaptation, saddle-shaped annuloplasty may increase repair durability. (C) 2015 by The Society of Thoracic Surgeons
|Number of pages||7|
|Journal||Annals of thoracic surgery|
|Publication status||Published - Oct-2015|
- POSTERIOR LEAFLET, MYOCARDIAL-INFARCTION, VALVE, GEOMETRY, REPLACEMENT, CURVATURE, SEVERITY, SURVIVAL, MODEL